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10.1002/sctm.17-0200 http://scihub22266oqcxt.onion/10.1002/sctm.17-0200 C6052610!6052610!29730892     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cells+Transl+Med 2018 ; 7 (7): 551-8 Nephropedia Template TP {{tp|p=29730892|t=2018. Activation of p70S6 Kinase?1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair |pdf=|usr=}}{{29730892}} gab.com Text Activation of p70S6 Kinase 1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29730892 #FOAvip All?trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase?1 (p70S6k1) activation in the repair process have not been defined. Twenty?one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty?two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured. After PPE, mice demonstrated increased values of Cst and MLI, and decreased S values. Both ATRA and MSC transfer were individually effective in improving these outcomes while the combination of ATRA and MSCs was even more effective. The combination of p70S6k1?/? MSCs transfer followed by ATRA demonstrated only modest effects, and rapamycin treatment of recipients with wild?type (WT) MSCs and ATRA failed to show any effect. However, transfer of p70S6k1 over?expressing?MSCs together with ATRA resulted in further improvements over those seen following WT MSCs together with ATRA. ATRA activated p70S6k1 in MSCs in vitro, which was completely inhibited by rapamycin. Tracking of transferred MSCs following ATRA revealed enhanced accumulation and extended survival of MSCs in recipient lungs following PPE but not vehicle instillation. These data suggest that in MSCs, p70S6k1 activation plays a critical role in ATRA?enhanced lung tissue repair, mediated in part by prolonged survival of transferred MSCs. p70S6k1?activated MSCs may represent a novel therapeutic approach to reverse the lung damage seen in emphysema. stemcellstranslationalmedicine2018;7:551?558 Twit Text FOAVip Activation of p70S6 Kinase 1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29730892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29730892 #FOAvip English Wikipedia <ref>{{Cite pmid|29730892}}</ref> Activation of p70S6 Kinase?1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair #MMPMID29730892 Takeda K; Ning F; Domenico J; Okamoto M; Ashino S; Kim S; Jeong YY; Shiraishi Y; Terada N; Sutherland ER; Gelfand EW Stem Cells Transl Med 2018[Jul]; 7 (7): 551-8 PMID29730892show ga All?trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase?1 (p70S6k1) activation in the repair process have not been defined. Twenty?one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty?two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured. After PPE, mice demonstrated increased values of Cst and MLI, and decreased S values. Both ATRA and MSC transfer were individually effective in improving these outcomes while the combination of ATRA and MSCs was even more effective. The combination of p70S6k1?/? MSCs transfer followed by ATRA demonstrated only modest effects, and rapamycin treatment of recipients with wild?type (WT) MSCs and ATRA failed to show any effect. However, transfer of p70S6k1 over?expressing?MSCs together with ATRA resulted in further improvements over those seen following WT MSCs together with ATRA. ATRA activated p70S6k1 in MSCs in vitro, which was completely inhibited by rapamycin. Tracking of transferred MSCs following ATRA revealed enhanced accumulation and extended survival of MSCs in recipient lungs following PPE but not vehicle instillation. These data suggest that in MSCs, p70S6k1 activation plays a critical role in ATRA?enhanced lung tissue repair, mediated in part by prolonged survival of transferred MSCs. p70S6k1?activated MSCs may represent a novel therapeutic approach to reverse the lung damage seen in emphysema. stemcellstranslationalmedicine2018;7:551?558 äActivation of p70S6 Kinase?1 in Mesenchymal Stem Cells Is Essential to(epmc).pdf DeepDyve Pubget Overpricing