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10.1038/s41598-018-29203-1 http://scihub22266oqcxt.onion/10.1038/s41598-018-29203-1 C6052061!6052061!30022148     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30022148|t=2018. Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-?B/GADD45B |pdf=|usr=}}{{30022148}} gab.com Text Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF- B/GADD45B JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30022148 #FOAvip Podocyte injury is a primary contributor to proteinuria. Triptolide is a major active component of Tripterygium wilfordii Hook F that exhibits potent antiproteinuric effects. We used our previously developed in vivo zebrafish model of inducible podocyte-target injury and found that triptolide treatment effectively alleviated oedema, proteinuria and foot process effacement. Triptolide also inhibited podocyte apoptosis in our zebrafish model and in vitro. We also examined the mechanism of triptolide protection of podocyte. Whole-genome expression profiles of cultured podocytes demonstrated that triptolide treatment downregulated apoptosis pathway-related GADD45B expression. Specific overexpression of gadd45b in zebrafish podocytes abolished the protective effects of triptolide. GADD45B is a mediator of podocyte apoptosis that contains typical NF-?B binding sites in the promoter region, and NF-?B p65 primarily transactivates this gene. Triptolide inhibited NF-?B signalling activation and binding of NF-?B to the GADD45B promoter. Taken together, our findings demonstrated that triptolide attenuated proteinuria and podocyte apoptosis via inhibition of NF-?B/GADD45B signalling, which provides a new understanding of the antiproteinuric effects of triptolide in glomerular diseases. Twit Text FOAVip Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF- B/GADD45B ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30022148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30022148 #FOAvip English Wikipedia <ref>{{Cite pmid|30022148}}</ref> Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-?B/GADD45B #MMPMID30022148 Wang L; Zhang L; Hou Q; Zhu X; Chen Z; Liu Z Sci Rep 2018[]; 8 (ä): ä PMID30022148show ga Podocyte injury is a primary contributor to proteinuria. Triptolide is a major active component of Tripterygium wilfordii Hook F that exhibits potent antiproteinuric effects. We used our previously developed in vivo zebrafish model of inducible podocyte-target injury and found that triptolide treatment effectively alleviated oedema, proteinuria and foot process effacement. Triptolide also inhibited podocyte apoptosis in our zebrafish model and in vitro. We also examined the mechanism of triptolide protection of podocyte. Whole-genome expression profiles of cultured podocytes demonstrated that triptolide treatment downregulated apoptosis pathway-related GADD45B expression. Specific overexpression of gadd45b in zebrafish podocytes abolished the protective effects of triptolide. GADD45B is a mediator of podocyte apoptosis that contains typical NF-?B binding sites in the promoter region, and NF-?B p65 primarily transactivates this gene. Triptolide inhibited NF-?B signalling activation and binding of NF-?B to the GADD45B promoter. Taken together, our findings demonstrated that triptolide attenuated proteinuria and podocyte apoptosis via inhibition of NF-?B/GADD45B signalling, which provides a new understanding of the antiproteinuric effects of triptolide in glomerular diseases. äTriptolide attenuates proteinuria and podocyte apoptosis via inhibitio(epmc).pdf DeepDyve Pubget Overpricing