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10.1016/j.nicl.2018.03.036 http://scihub22266oqcxt.onion/10.1016/j.nicl.2018.03.036 C6051941!6051941!30035002     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroimage+Clin 2018 ; 19 (ä): 56-65 Nephropedia Template TP {{tp|p=30035002|t=2018. Sleep apnea: Altered brain connectivity underlying a working-memory challenge |pdf=|usr=}}{{30035002}} gab.com Text Sleep apnea: Altered brain connectivity underlying a working-memory challenge JO: Neuroimage Clin http://www.kidney.de/pget.php?&tw=1&pmid=30035002 #FOAvip Obstructive sleep apnea (OSA) is characterized by the frequent presence of neuro-cognitive impairment. Recent studies associate cognitive dysfunction with altered resting-state brain connectivity between key nodes of the executive and default-mode networks, two anti-correlated functional networks whose strength of activation increases or decreases with cognitive activity, respectively. To date no study has investigated a relationship between cognitive impairment in OSA and brain connectivity during an active working-memory challenge. We thus investigated the effect of OSA on working-memory performance and underlying brain connectivity.OSA patients and matched healthy controls underwent functional magnetic resonance imaging (fMRI) scanning while performing a 2-back working-memory task. Standard fMRI analyses highlighted the brain regions activated at increasing levels of working-memory load, which were used as seeds in connectivity analyses. The latter were based on a multiregional Psycho-Physiological-Interaction (PPI) approach, to unveil group differences in effective connectivity underlying working-memory performance.Compared with controls, in OSA patients normal working-memory performance reflected in: a) reduced interhemispheric effective connectivity between the frontal ?executive? nodes of the working-memory network, and b) increased right-hemispheric connectivity among regions mediating the ?salience-based? switch from the default resting-state mode to the effortful cognitive activity associated with the executive network. The strength of such connections was correlated, at increasing task-demands, with executive (Stroop test) and memory (Digit Span test) performance in neuro-cognitive evaluations.The analysis of effective connectivity changes during a working-memory challenge provides a complementary window, compared with resting-state studies, on the mechanisms supporting preserved performance despite functional and structural brain modifications in OSA. Twit Text FOAVip Sleep apnea: Altered brain connectivity underlying a working-memory challenge ????Neuroimage Clin http://www.kidney.de/pget.php?&tw=1&pmid=30035002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30035002 #FOAvip English Wikipedia <ref>{{Cite pmid|30035002}}</ref> Sleep apnea: Altered brain connectivity underlying a working-memory challenge #MMPMID30035002 Canessa N; Castronovo V; Cappa SF; Marelli S; Iadanza A; Falini A; Ferini-Strambi L Neuroimage Clin 2018[]; 19 (ä): 56-65 PMID30035002show ga Obstructive sleep apnea (OSA) is characterized by the frequent presence of neuro-cognitive impairment. Recent studies associate cognitive dysfunction with altered resting-state brain connectivity between key nodes of the executive and default-mode networks, two anti-correlated functional networks whose strength of activation increases or decreases with cognitive activity, respectively. To date no study has investigated a relationship between cognitive impairment in OSA and brain connectivity during an active working-memory challenge. We thus investigated the effect of OSA on working-memory performance and underlying brain connectivity.OSA patients and matched healthy controls underwent functional magnetic resonance imaging (fMRI) scanning while performing a 2-back working-memory task. Standard fMRI analyses highlighted the brain regions activated at increasing levels of working-memory load, which were used as seeds in connectivity analyses. The latter were based on a multiregional Psycho-Physiological-Interaction (PPI) approach, to unveil group differences in effective connectivity underlying working-memory performance.Compared with controls, in OSA patients normal working-memory performance reflected in: a) reduced interhemispheric effective connectivity between the frontal ?executive? nodes of the working-memory network, and b) increased right-hemispheric connectivity among regions mediating the ?salience-based? switch from the default resting-state mode to the effortful cognitive activity associated with the executive network. The strength of such connections was correlated, at increasing task-demands, with executive (Stroop test) and memory (Digit Span test) performance in neuro-cognitive evaluations.The analysis of effective connectivity changes during a working-memory challenge provides a complementary window, compared with resting-state studies, on the mechanisms supporting preserved performance despite functional and structural brain modifications in OSA. äSleep apnea: Altered brain connectivity underlying a working-memory ch(epmc).pdf DeepDyve Pubget Overpricing