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10.1042/NS20170010 http://scihub22266oqcxt.onion/10.1042/NS20170010 C6051536!6051536!30034823     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuronal+Signal 2017 ; 1 (4): ä Nephropedia Template TP {{tp|p=30034823|t=2017. Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms |pdf=|usr=}}{{30034823}} gab.com Text Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms JO: Neuronal Signal http://www.kidney.de/pget.php?&tw=1&pmid=30034823 #FOAvip Depression is a chronic, debilitating, and common illness. Currently available pharmacotherapies can be helpful but have several major drawbacks, including substantial rates of low or no response and a long therapeutic time lag. In pursuit of better treatment options, recent research has focussed on rapid-acting antidepressants, including the N-methyl-d-aspartate (NMDA) receptor (NMDAR) antagonist ketamine, which affects a range of signaling pathways in ways that are distinct from the mechanisms of typical antidepressants. Because ketamine and similar drugs hold the promise of dramatically improving treatment options for depressed patients, there has been considerable interest in developing new ways to understand how these compounds affect the brain. Here, we review the current understanding of how rapid-acting antidepressants function, including their effects on neuronal signaling pathways and neural circuits, and the research techniques being used to address these questions. Twit Text FOAVip Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms ????Neuronal Signal http://www.kidney.de/pget.php?&tw=1&pmid=30034823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30034823 #FOAvip English Wikipedia <ref>{{Cite pmid|30034823}}</ref> Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms #MMPMID30034823 Thomas A; Duman R Neuronal Signal 2017[Dec]; 1 (4): ä PMID30034823show ga Depression is a chronic, debilitating, and common illness. Currently available pharmacotherapies can be helpful but have several major drawbacks, including substantial rates of low or no response and a long therapeutic time lag. In pursuit of better treatment options, recent research has focussed on rapid-acting antidepressants, including the N-methyl-d-aspartate (NMDA) receptor (NMDAR) antagonist ketamine, which affects a range of signaling pathways in ways that are distinct from the mechanisms of typical antidepressants. Because ketamine and similar drugs hold the promise of dramatically improving treatment options for depressed patients, there has been considerable interest in developing new ways to understand how these compounds affect the brain. Here, we review the current understanding of how rapid-acting antidepressants function, including their effects on neuronal signaling pathways and neural circuits, and the research techniques being used to address these questions. äNovel rapid-acting antidepressants: molecular and cellular signaling m(epmc).pdf DeepDyve Pubget Overpricing