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10.1038/s41593-018-0071-y http://scihub22266oqcxt.onion/10.1038/s41593-018-0071-y C6051351!6051351!29379116     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2018 ; 21 (3): 404-14 Nephropedia Template TP {{tp|p=29379116|t=2018. Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli |pdf=|usr=}}{{29379116}} gab.com Text Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29379116 #FOAvip Social animals detect the affective states of conspecifics and utilize this information to orchestrate social interactions. In a novel social affective preference text in which experimental adult male rats could interact with either naive or stressed conspecifics, the experimental rats either approached or avoided the stressed conspecific, depending upon the age of the conspecific. Specifically, experimental rats approached stressed juveniles but avoided stressed adults. Inhibition of insular cortex, which is implicated in social cognition, and blockade of insular oxytocin receptors disrupted the social affective behaviors. Oxytocin application increased intrinsic excitability and synaptic efficacy in acute insular cortex slices, and insular oxytocin administration recapitulated the behaviors observed toward stressed conspecifics. Network analysis of Fos immunoreactivity in 29 regions identified functional connectivity between insular cortex, prefrontal cortex, amygdala and the social decision-making network. These results implicate insular cortex as a key component in the circuit underlying age-dependent social responses to stressed conspecifics. Twit Text FOAVip Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29379116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29379116 #FOAvip English Wikipedia <ref>{{Cite pmid|29379116}}</ref> Insular Cortex Mediates Approach and Avoidance Responses to Social Affective Stimuli #MMPMID29379116 Rogers-Carter MM; Varela JA; Gribbons KB; Pierce AF; McGoey MT; Ritchey M; Christianson JP Nat Neurosci 2018[Mar]; 21 (3): 404-14 PMID29379116show ga Social animals detect the affective states of conspecifics and utilize this information to orchestrate social interactions. In a novel social affective preference text in which experimental adult male rats could interact with either naive or stressed conspecifics, the experimental rats either approached or avoided the stressed conspecific, depending upon the age of the conspecific. Specifically, experimental rats approached stressed juveniles but avoided stressed adults. Inhibition of insular cortex, which is implicated in social cognition, and blockade of insular oxytocin receptors disrupted the social affective behaviors. Oxytocin application increased intrinsic excitability and synaptic efficacy in acute insular cortex slices, and insular oxytocin administration recapitulated the behaviors observed toward stressed conspecifics. Network analysis of Fos immunoreactivity in 29 regions identified functional connectivity between insular cortex, prefrontal cortex, amygdala and the social decision-making network. These results implicate insular cortex as a key component in the circuit underlying age-dependent social responses to stressed conspecifics. äInsular Cortex Mediates Approach and Avoidance Responses to Social Aff(epmc).pdf DeepDyve Pubget Overpricing