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10.1002/cam4.1528 http://scihub22266oqcxt.onion/10.1002/cam4.1528 C6051168!6051168!29749104     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Med 2018 ; 7 (7): 3168-77 Nephropedia Template TP {{tp|p=29749104|t=2018. Soluble fibrinogen?like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization |pdf=|usr=}}{{29749104}} gab.com Text Soluble fibrinogen like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization JO: Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=29749104 #FOAvip Soluble fibrinogen?like protein 2 (sFGL2) could ameliorate acute rejection (AR) in rat cardiac transplantation. However, the role of sFGL2 in AR of liver transplantation has not been addressed. In this study, we found that FGL2 was upregulated in rat orthotropic liver transplantation (OLT) models of tolerance and positive correlation with the frequency of M2 Kupffer cells (KCs). Gain?of?function experiments in vitro showed that sFGL2 promoted the secretion of anti?inflammatory cytokines (IL?10, TGF??) and the expression of CD206, and inhibited the activities of STAT1 and NF??B signaling pathway. Consistently, in vivo assays showed that adeno?associated virus?mediated FGL2 (AAV?FGL2) transfer to recipients could ameliorate AR of rat OLT and induce KCs M2 polarization in allografts. Notably, we found that the recipients receiving transferred KCs from AAV?FGL2?treated allograft showed alleviated AR. Taken together, we revealed that sFGL2 ameliorated AR by inducing KCs M2 polarization. Twit Text FOAVip Soluble fibrinogen like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization ????Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=29749104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29749104 #FOAvip English Wikipedia <ref>{{Cite pmid|29749104}}</ref> Soluble fibrinogen?like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization #MMPMID29749104 Pan G; Zhao Z; Tang C; Ding L; Li Z; Zheng D; Zong L; Wu Z Cancer Med 2018[Jul]; 7 (7): 3168-77 PMID29749104show ga Soluble fibrinogen?like protein 2 (sFGL2) could ameliorate acute rejection (AR) in rat cardiac transplantation. However, the role of sFGL2 in AR of liver transplantation has not been addressed. In this study, we found that FGL2 was upregulated in rat orthotropic liver transplantation (OLT) models of tolerance and positive correlation with the frequency of M2 Kupffer cells (KCs). Gain?of?function experiments in vitro showed that sFGL2 promoted the secretion of anti?inflammatory cytokines (IL?10, TGF??) and the expression of CD206, and inhibited the activities of STAT1 and NF??B signaling pathway. Consistently, in vivo assays showed that adeno?associated virus?mediated FGL2 (AAV?FGL2) transfer to recipients could ameliorate AR of rat OLT and induce KCs M2 polarization in allografts. Notably, we found that the recipients receiving transferred KCs from AAV?FGL2?treated allograft showed alleviated AR. Taken together, we revealed that sFGL2 ameliorated AR by inducing KCs M2 polarization. äSoluble fibrinogen?like protein 2 ameliorates acute rejection of liver(epmc).pdf DeepDyve Pubget Overpricing