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Soluble fibrinogen-like protein 2 ameliorates acute rejection of liver
transplantation in rat via inducing Kupffer cells M2 polarization
#MMPMID29749104
Pan G
; Zhao Z
; Tang C
; Ding L
; Li Z
; Zheng D
; Zong L
; Wu Z
Cancer Med
2018[Jul]; 7
(7
): 3168-3177
PMID29749104
show ga
Soluble fibrinogen-like protein 2 (sFGL2) could ameliorate acute rejection (AR)
in rat cardiac transplantation. However, the role of sFGL2 in AR of liver
transplantation has not been addressed. In this study, we found that FGL2 was
upregulated in rat orthotropic liver transplantation (OLT) models of tolerance
and positive correlation with the frequency of M2 Kupffer cells (KCs).
Gain-of-function experiments in vitro showed that sFGL2 promoted the secretion of
anti-inflammatory cytokines (IL-10, TGF-?) and the expression of CD206, and
inhibited the activities of STAT1 and NF-?B signaling pathway. Consistently, in
vivo assays showed that adeno-associated virus-mediated FGL2 (AAV-FGL2) transfer
to recipients could ameliorate AR of rat OLT and induce KCs M2 polarization in
allografts. Notably, we found that the recipients receiving transferred KCs from
AAV-FGL2-treated allograft showed alleviated AR. Taken together, we revealed that
sFGL2 ameliorated AR by inducing KCs M2 polarization.
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