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Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow
Cells, Bone Properties, and Hepatic and Renal Morphology of Rats
#MMPMID30057490
Cardoso de Sousa M
; Vegian MRDC
; Biserra MA
; Costa BCA
; Camargo SEA
; Rode SM
; Ramos CJ
; Dias de Oliveira L
; de Vasconcellos LMR
ScientificWorldJournal
2018[]; 2018
(?): 2494918
PMID30057490
show ga
Chronic alcohol exposure can affect the osteoblastic activity and the
proliferation and differentiation of cells due to its toxic effect, which can
affect negatively bone repair and bone microarchitecture. The aim of this study
was to evaluate the effects of chronic use of 20% alcohol on rats regarding
osteoblastic differentiation, extrinsic and intrinsic properties of the tibia,
and hepatic and renal morphology. Wistar rats were divided into three groups (n =
9) in accordance with a 24-week diet. After euthanasia, kidneys, liver, and
tibias were removed for analysis and femurs mesenchymal cells were collected. The
results showed that chronic use of 20% alcohol influenced neither the alkaline
phosphatase production nor total protein (p > 0.05) in rats, with similar
formation of nodules in all groups (p > 0.05). However, significant changes in
the liver and kidneys and adverse effects on the mechanical properties of the
tibia were observed. According to the results, it can be concluded that the
chronic use of alcohol for 24 weeks had no negative influence on the activity and
differentiation of osteoblasts, but the mechanical properties of the tibia were
impaired and the organs responsible for metabolism and excretion were also
affected due to the consumption of alcohol.
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