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10.1155/2018/4545321 http://scihub22266oqcxt.onion/10.1155/2018/4545321 C6051041!6051041!30057680     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oxid+Med+Cell+Longev 2018 ; 2018 (ä): ä Nephropedia Template TP {{tp|p=30057680|t=2018. Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-? Signaling Pathway Activation in Type 2 Diabetic Rats |pdf=|usr=}}{{30057680}} gab.com Text Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF- Signaling Pathway Activation in Type 2 Diabetic Rats JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=30057680 #FOAvip Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism are still unclear. The current study was designed to explore the therapeutic effect and mechanism of PUR on liver injury in a type 2 diabetic rat model induced by a high-fat diet combined with low-dose streptozotocin. The diabetic rats were treated with or without PUR (100?mg/kg/day) by gavaging for 8 weeks, and biochemical and histological changes in liver were examined. Results showed that treatment with PUR significantly attenuated hepatic steatosis by regulating blood glucose and ameliorating lipid metabolism disorder. Liver fibrosis was relieved by PUR treatment. PUR inhibited oxidative stress and inflammation which was associated with inactivation of NF-?B signaling, thereby blocking the upregulation of proinflammatory cytokines (IL-1?, TNF-?) and chemokine (MCP-1). This protection of PUR on diabetic liver injury is possibly related with inhibition on TGF-?/Smad signaling. In conclusion, the present study provides evidence that PUR attenuated type 2 diabetic liver injury by inhibiting NF-?B-driven liver inflammation and the TGF-?/Smad signaling pathway. Twit Text FOAVip Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF- Signaling Pathway Activation in Type 2 Diabetic Rats ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=30057680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30057680 #FOAvip English Wikipedia <ref>{{Cite pmid|30057680}}</ref> Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-? Signaling Pathway Activation in Type 2 Diabetic Rats #MMPMID30057680 Hou B; Zhao Y; Qiang G; Yang X; Xu C; Chen X; Liu C; Wang X; Zhang L; Du G Oxid Med Cell Longev 2018[]; 2018 (ä): ä PMID30057680show ga Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism are still unclear. The current study was designed to explore the therapeutic effect and mechanism of PUR on liver injury in a type 2 diabetic rat model induced by a high-fat diet combined with low-dose streptozotocin. The diabetic rats were treated with or without PUR (100?mg/kg/day) by gavaging for 8 weeks, and biochemical and histological changes in liver were examined. Results showed that treatment with PUR significantly attenuated hepatic steatosis by regulating blood glucose and ameliorating lipid metabolism disorder. Liver fibrosis was relieved by PUR treatment. PUR inhibited oxidative stress and inflammation which was associated with inactivation of NF-?B signaling, thereby blocking the upregulation of proinflammatory cytokines (IL-1?, TNF-?) and chemokine (MCP-1). This protection of PUR on diabetic liver injury is possibly related with inhibition on TGF-?/Smad signaling. In conclusion, the present study provides evidence that PUR attenuated type 2 diabetic liver injury by inhibiting NF-?B-driven liver inflammation and the TGF-?/Smad signaling pathway. äPuerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiti(epmc).pdf DeepDyve Pubget Overpricing