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10.1155/2018/4083921 http://scihub22266oqcxt.onion/10.1155/2018/4083921 C6051015!6051015!30057622     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cells+Int 2018 ; 2018 (ä): ä Nephropedia Template TP {{tp|p=30057622|t=2018. Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization |pdf=|usr=}}{{30057622}} gab.com Text Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization JO: Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=30057622 #FOAvip Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense research by academia and industry due to their unique features. MSC can be easily isolated and expanded through in vitro culture by taking full advantage of their self-renewing capacity. In addition, MSC exert immunomodulatory effects and can be differentiated into various lineages, which makes them highly attractive for clinical applications in cell-based therapies. In this review, we attempt to provide a brief historical overview of MSC discovery, characterization, and the first clinical studies conducted. The current MSC manufacturing platforms are reviewed with special attention regarding the use of bioreactors for the production of GMP-compliant clinically relevant cell numbers. The first commercial MSC-based products are also addressed, as well as the remaining challenges to the widespread use of MSC-derived products. Twit Text FOAVip Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization ????Stem Cells Int http://www.kidney.de/pget.php?&tw=1&pmid=30057622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30057622 #FOAvip English Wikipedia <ref>{{Cite pmid|30057622}}</ref> Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization #MMPMID30057622 Mizukami A; Swiech K Stem Cells Int 2018[]; 2018 (ä): ä PMID30057622show ga Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense research by academia and industry due to their unique features. MSC can be easily isolated and expanded through in vitro culture by taking full advantage of their self-renewing capacity. In addition, MSC exert immunomodulatory effects and can be differentiated into various lineages, which makes them highly attractive for clinical applications in cell-based therapies. In this review, we attempt to provide a brief historical overview of MSC discovery, characterization, and the first clinical studies conducted. The current MSC manufacturing platforms are reviewed with special attention regarding the use of bioreactors for the production of GMP-compliant clinically relevant cell numbers. The first commercial MSC-based products are also addressed, as well as the remaining challenges to the widespread use of MSC-derived products. äMesenchymal Stromal Cells: From Discovery to Manufacturing and Commerc(epmc).pdf DeepDyve Pubget Overpricing