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10.1177/2055217318787829 http://scihub22266oqcxt.onion/10.1177/2055217318787829 C6050870!6050870 !30038790     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30038790 &cmd=llinks): Failed to open stream: HTTP request failed! 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MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response |pdf=|usr=}}{{30038790 }} gab.com Text MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response JO: Mult Scler J Exp Transl Clin http://www.kidney.de/pget.php?&tw=1&pmid=30038790 #FOAvip OBJECTIVES: We investigated the clinical characteristics and treatment response in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease and looked for evidence of subclinical disease. METHODS: We prospectively evaluated the frequency and pattern of relapse, tested afferent visual function and monitored treatment response in 42 south Asian patients from a single centre. RESULTS: Eighteen patients (42.9%) had monophasic and 24 (57.1%) a relapsing course. Disease duration was longer (P<0.02) in those with a relapsing course. Median time to the second attack was prolonged (P<0.04) in patients with recurrent transverse myelitis when compared with neuromyelitis optica spectrum disorder and recurrent optic neuritis. Thirteen out of 17 patients (76.5%) initially presenting with optic neuritis developed recurrent optic neuritis later. After the first attack of transverse myelitis, 17 out of 22 (77.3%) had disease confined to the spinal cord. Optical coherence tomography detected peripapillary retinal nerve fibre layer thickness (P<0.05) and macular ganglion cell complex volume (P<0.005) abnormalities in seven out of 10 (70.0%) patients without clinical optic neuritis. Immunosuppressants induced remission in 17 out of 22 (77.3%) patients during a median follow-up of 48 months and the median Expanded Disability Status Score was 1 (range 1-10). CONCLUSION: Our study highlighted the tendency for stereotypical attacks in MOG-IgG-associated disease, heterogeneity in clinical course among subtypes, subclinical visual impairment and the need for early and sustained immunosuppressive therapy. Twit Text FOAVip MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response ????Mult Scler J Exp Transl Clin http://www.kidney.de/pget.php?&tw=1&pmid=30038790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30038790 #FOAvip English Wikipedia <ref>{{Cite pmid|30038790 }}</ref> MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response #MMPMID30038790 Pandit L ; Mustafa S ; Nakashima I ; Takahashi T ; Kaneko K Mult Scler J Exp Transl Clin 2018[Jul]; 4 (3 ): 2055217318787829 PMID30038790 show ga OBJECTIVES: We investigated the clinical characteristics and treatment response in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease and looked for evidence of subclinical disease. METHODS: We prospectively evaluated the frequency and pattern of relapse, tested afferent visual function and monitored treatment response in 42 south Asian patients from a single centre. RESULTS: Eighteen patients (42.9%) had monophasic and 24 (57.1%) a relapsing course. Disease duration was longer (P<0.02) in those with a relapsing course. Median time to the second attack was prolonged (P<0.04) in patients with recurrent transverse myelitis when compared with neuromyelitis optica spectrum disorder and recurrent optic neuritis. Thirteen out of 17 patients (76.5%) initially presenting with optic neuritis developed recurrent optic neuritis later. After the first attack of transverse myelitis, 17 out of 22 (77.3%) had disease confined to the spinal cord. Optical coherence tomography detected peripapillary retinal nerve fibre layer thickness (P<0.05) and macular ganglion cell complex volume (P<0.005) abnormalities in seven out of 10 (70.0%) patients without clinical optic neuritis. Immunosuppressants induced remission in 17 out of 22 (77.3%) patients during a median follow-up of 48 months and the median Expanded Disability Status Score was 1 (range 1-10). CONCLUSION: Our study highlighted the tendency for stereotypical attacks in MOG-IgG-associated disease, heterogeneity in clinical course among subtypes, subclinical visual impairment and the need for early and sustained immunosuppressive therapy. äMOG-IgG-associated disease has a stereotypical clinical course, asympt(epmc).pdf DeepDyve Pubget Overpricing