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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Transl+Allergy
2018 ; 8
(ä): 27
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English Wikipedia
Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE
antibodies to eliminating IgE(+) B cells
#MMPMID30026908
Hu J
; Chen J
; Ye L
; Cai Z
; Sun J
; Ji K
Clin Transl Allergy
2018[]; 8
(ä): 27
PMID30026908
show ga
Allergic diseases are inflammatory disorders that involve many types of cells and
factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils,
cytokines and soluble mediators. Among them, IgE plays a vital role in the
development of acute allergic reactions and chronic inflammatory allergic
diseases, making its control particularly important in the treatment of
IgE-mediated allergic diseases. This review provides an overview of the current
state of IgE targeted therapy development, focusing on three areas of
translational research: IgE neutralization in blood; IgE-effector cell
elimination; and IgE(+) B cell reduction. IgE-targeted medicines such as FDA
approved drug Xolair (Omalizumab) represent a promising avenue for treating
IgE-mediated allergic diseases given the pernicious role of IgE in disease
progression. Additionally, targeted therapy for IgE-mediated allergic diseases
may be advanced through cellular treatments, including the modification of
effector cells.