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10.1159/000490334 http://scihub22266oqcxt.onion/10.1159/000490334 C6050514!6050514!29870994     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Blood+Press+Res 2018 ; 43 (3): 860-71 Nephropedia Template TP {{tp|p=29870994|t=2018. Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice |pdf=|usr=}}{{29870994}} gab.com Text Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice JO: Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=29870994 #FOAvip Background/Aims:: Canonical Wnt signaling is involved in oxidative stress, vasculopathy and diabetes mellitus but its role in diabetic renal microvascular dysfunction is unclear. We tested the hypothesis that enhanced canonical Wnt signaling in renal afferent arterioles from diabetic mice increases reactive oxygen species (ROS) and contractions to endothelin-1 (ET-1). Methods:: Streptozotocin-induced diabetes or control C57BI/6 mice received vehicle or sulindac (40 mg·kg?1·day?1) to block Wnt signaling for 4 weeks. ET-1 contractions were measured by changes of afferent arteriolar diameter. Arteriolar H2O2, O2.?, protein expression and enzymatic activity were assessed using sensitive fluorescence probes, immunoblotting and colorimetric assay separately. Results:: Compared to control, diabetic mouse afferent arteriole had increased O2?(+ 84%) and H2O2 (+ 91%) and enhanced responses to ET-1 at 10?8 mol·l?1 (?72±4% of versus ?43±4%, P<0.05) accompanied by reduced protein expressions and activities for catalase and superoxide dismutase 2 (SOD2). Arteriolar O2.? was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice. The Wnt signaling protein ?-catenin was upregulated (3.3-fold decrease in p-?-catenin/?-catenin) while the glycogen synthase kinase-3? (GSK-3?) was downregulated (2.6-fold increase in p-GSK-3?/GSK-3?) in preglomerular vessels of diabetic mice. Sulindac normalized the Wnt signaling proteins, arteriolar O2.?, H2O2 and ET-1 contractions while doubling microvascular catalase and SOD2 expression in diabetic mice. Conclusion:: Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling. Antioxidant pharmacological strategies targeting Wnt signaling may improve vascular function in diabetic nephropathy. Twit Text FOAVip Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice ????Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=29870994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29870994 #FOAvip English Wikipedia <ref>{{Cite pmid|29870994}}</ref> Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice #MMPMID29870994 Zhang S; Huang Q; Wang Q; Wang Q; Cao X; Zhao L; Xu N; Zhuge Z; Mao J; Fu X; Liu R; Wilcox CS; Patzak A; Li L; Lai EY Kidney Blood Press Res 2018[]; 43 (3): 860-71 PMID29870994show ga Background/Aims:: Canonical Wnt signaling is involved in oxidative stress, vasculopathy and diabetes mellitus but its role in diabetic renal microvascular dysfunction is unclear. We tested the hypothesis that enhanced canonical Wnt signaling in renal afferent arterioles from diabetic mice increases reactive oxygen species (ROS) and contractions to endothelin-1 (ET-1). Methods:: Streptozotocin-induced diabetes or control C57BI/6 mice received vehicle or sulindac (40 mg·kg?1·day?1) to block Wnt signaling for 4 weeks. ET-1 contractions were measured by changes of afferent arteriolar diameter. Arteriolar H2O2, O2.?, protein expression and enzymatic activity were assessed using sensitive fluorescence probes, immunoblotting and colorimetric assay separately. Results:: Compared to control, diabetic mouse afferent arteriole had increased O2?(+ 84%) and H2O2 (+ 91%) and enhanced responses to ET-1 at 10?8 mol·l?1 (?72±4% of versus ?43±4%, P<0.05) accompanied by reduced protein expressions and activities for catalase and superoxide dismutase 2 (SOD2). Arteriolar O2.? was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice. The Wnt signaling protein ?-catenin was upregulated (3.3-fold decrease in p-?-catenin/?-catenin) while the glycogen synthase kinase-3? (GSK-3?) was downregulated (2.6-fold increase in p-GSK-3?/GSK-3?) in preglomerular vessels of diabetic mice. Sulindac normalized the Wnt signaling proteins, arteriolar O2.?, H2O2 and ET-1 contractions while doubling microvascular catalase and SOD2 expression in diabetic mice. Conclusion:: Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling. Antioxidant pharmacological strategies targeting Wnt signaling may improve vascular function in diabetic nephropathy. äEnhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contrac(epmc).pdf DeepDyve Pubget Overpricing