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10.1038/s41467-018-05176-7 http://scihub22266oqcxt.onion/10.1038/s41467-018-05176-7 C6050289!6050289 !30018336     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30018336 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 2789 Nephropedia Template TP {{tp|p=30018336 |t=2018. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop |pdf=|usr=}}{{30018336 }} gab.com Text Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30018336 #FOAvip Interferon (IFN)-stimulated genes (ISGs) play crucial roles in the antiviral immune response; however, IFNs also induce negative regulators that attenuate the antiviral response. Here, we show that both viral and bacterial invasion downregulate Nuclear Dbf2-related kinase 1 (NDR1) expression via the type I IFN signaling pathway. NDR1 promotes the virus-induced production of type I IFN, proinflammatory cytokines and ISGs in a kinase-independent manner. NDR1 deficiency also renders mice more susceptible to viral and bacterial infections. Mechanistically, NDR1 enhances STAT1 translation by directly binding to the intergenic region of miR146a, thereby inhibiting miR146a expression and liberating STAT1 from miR146a-mediated translational inhibition. Furthermore, STAT1 binds to the miR146a promoter, thus decreasing its expression. Together, our results suggest that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response, and suggest that NDR1 has an important role in controlling viral infections. Twit Text FOAVip Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30018336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30018336 #FOAvip English Wikipedia <ref>{{Cite pmid|30018336 }}</ref> Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop #MMPMID30018336 Liu Z ; Qin Q ; Wu C ; Li H ; Shou J ; Yang Y ; Gu M ; Ma C ; Lin W ; Zou Y ; Zhang Y ; Ma F ; Sun J ; Wang X Nat Commun 2018[Jul]; 9 (1 ): 2789 PMID30018336 show ga Interferon (IFN)-stimulated genes (ISGs) play crucial roles in the antiviral immune response; however, IFNs also induce negative regulators that attenuate the antiviral response. Here, we show that both viral and bacterial invasion downregulate Nuclear Dbf2-related kinase 1 (NDR1) expression via the type I IFN signaling pathway. NDR1 promotes the virus-induced production of type I IFN, proinflammatory cytokines and ISGs in a kinase-independent manner. NDR1 deficiency also renders mice more susceptible to viral and bacterial infections. Mechanistically, NDR1 enhances STAT1 translation by directly binding to the intergenic region of miR146a, thereby inhibiting miR146a expression and liberating STAT1 from miR146a-mediated translational inhibition. Furthermore, STAT1 binds to the miR146a promoter, thus decreasing its expression. Together, our results suggest that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response, and suggest that NDR1 has an important role in controlling viral infections. |*Feedback, Physiological [MESH] |Animals [MESH] |Bronchiolitis, Viral/*genetics/immunology/virology [MESH] |Case-Control Studies [MESH] |Child [MESH] |Gene Expression Regulation [MESH] |HEK293 Cells [MESH] |Herpesvirus 1, Human/*genetics/immunology [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Interferon-alpha/genetics/immunology [MESH] |Interferon-beta/genetics/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |MicroRNAs/*genetics/immunology [MESH] |Protein Biosynthesis [MESH] |Protein Serine-Threonine Kinases/deficiency/*genetics/immunology [MESH] |RAW 264.7 Cells [MESH] |Respiratory Syncytial Virus, Human/genetics/immunology [MESH] |STAT1 Transcription Factor/*genetics/immunology [MESH] |Signal Transduction [MESH]Downregulated NDR1 protein kinase inhibits innate immune response by i(epmc).pdf DeepDyve Pubget Overpricing