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10.1038/s41467-018-05168-7 http://scihub22266oqcxt.onion/10.1038/s41467-018-05168-7 C6050272!6050272!30018345     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30018345|t=2018. A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling |pdf=|usr=}}{{30018345}} gab.com Text A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30018345 #FOAvip Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by type I interferons (IFNs). While viral RNA and DNA species induce IFN via separate pathways, the mechanisms by which these pathways are differentially modulated are unknown. Here we show that the positive regulator of IFN in the RNA pathway, TRAF3, has an inhibitory function in the DNA pathway. Loss of TRAF3 coincides with increased expression of the alternative NF-?B-inducing molecule, NIK, which interacts with the DNA pathway adaptor, STING, to enhance IFN induction. Cells lacking NIK display defective IFN activation in the DNA pathway due to impaired STING signaling, and NIK-deficient mice are more susceptible to DNA virus infection. Mechanistically, NIK operates independently from alternative NF-?B signaling components and instead requires autophosphorylation and oligomerization to activate STING. Thus a previously undescribed pathway for NIK exists in activating IFN in the DNA pathway. Twit Text FOAVip A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30018345 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30018345 #FOAvip English Wikipedia <ref>{{Cite pmid|30018345}}</ref> A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling #MMPMID30018345 Parvatiyar K; Pindado J; Dev A; Aliyari SR; Zaver SA; Gerami H; Chapon M; Ghaffari AA; Dhingra A; Cheng G Nat Commun 2018[]; 9 (ä): ä PMID30018345show ga Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by type I interferons (IFNs). While viral RNA and DNA species induce IFN via separate pathways, the mechanisms by which these pathways are differentially modulated are unknown. Here we show that the positive regulator of IFN in the RNA pathway, TRAF3, has an inhibitory function in the DNA pathway. Loss of TRAF3 coincides with increased expression of the alternative NF-?B-inducing molecule, NIK, which interacts with the DNA pathway adaptor, STING, to enhance IFN induction. Cells lacking NIK display defective IFN activation in the DNA pathway due to impaired STING signaling, and NIK-deficient mice are more susceptible to DNA virus infection. Mechanistically, NIK operates independently from alternative NF-?B signaling components and instead requires autophosphorylation and oligomerization to activate STING. Thus a previously undescribed pathway for NIK exists in activating IFN in the DNA pathway. äA TRAF3-NIK module differentially regulates DNA vs RNA pathways in inn(epmc).pdf DeepDyve Pubget Overpricing