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10.1371/journal.ppat.1007157 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1007157 C6049935!6049935!30016370     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2018 ; 14 (7): ä Nephropedia Template TP {{tp|p=30016370|t=2018. Neutrophils use superoxide to control bacterial infection at a distance |pdf=|usr=}}{{30016370}} gab.com Text Neutrophils use superoxide to control bacterial infection at a distance JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=30016370 #FOAvip Understanding the roles of neutrophils and macrophages in fighting bacterial infections is a critical issue in human pathologies. Although phagocytic killing has been extensively studied, little is known about how bacteria are eliminated extracellularly in live vertebrates. We have recently developed an infection model in the zebrafish embryo in which leukocytes cannot reach the injected bacteria. When Escherichia coli bacteria are injected within the notochord, both neutrophils and macrophages are massively recruited during several days, but do not infiltrate the infected tissue presumably because of its tough collagen sheath. Nevertheless, the bacteria are killed during the first 24 hours, and we report here that neutrophils, but not macrophages are involved in the control of the infection. Using genetic and chemical approaches, we show that even in absence of phagocytosis, the bactericidal action relies on NADPH oxidase-dependent production of superoxide in neutrophils. We thus reveal a host effector mechanism mediated by neutrophils that eliminates bacteria that cannot be reached by phagocytes and that is independent of macrophages, NO synthase or myeloperoxidase. Twit Text FOAVip Neutrophils use superoxide to control bacterial infection at a distance ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=30016370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30016370 #FOAvip English Wikipedia <ref>{{Cite pmid|30016370}}</ref> Neutrophils use superoxide to control bacterial infection at a distance #MMPMID30016370 Phan QT; Sipka T; Gonzalez C; Levraud JP; Lutfalla G; Nguyen-Chi M PLoS Pathog 2018[Jul]; 14 (7): ä PMID30016370show ga Understanding the roles of neutrophils and macrophages in fighting bacterial infections is a critical issue in human pathologies. Although phagocytic killing has been extensively studied, little is known about how bacteria are eliminated extracellularly in live vertebrates. We have recently developed an infection model in the zebrafish embryo in which leukocytes cannot reach the injected bacteria. When Escherichia coli bacteria are injected within the notochord, both neutrophils and macrophages are massively recruited during several days, but do not infiltrate the infected tissue presumably because of its tough collagen sheath. Nevertheless, the bacteria are killed during the first 24 hours, and we report here that neutrophils, but not macrophages are involved in the control of the infection. Using genetic and chemical approaches, we show that even in absence of phagocytosis, the bactericidal action relies on NADPH oxidase-dependent production of superoxide in neutrophils. We thus reveal a host effector mechanism mediated by neutrophils that eliminates bacteria that cannot be reached by phagocytes and that is independent of macrophages, NO synthase or myeloperoxidase. äNeutrophils use superoxide to control bacterial infection at a distanc(epmc).pdf DeepDyve Pubget Overpricing