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10.18632/oncotarget.25636 http://scihub22266oqcxt.onion/10.18632/oncotarget.25636 C6049853!6049853 !30038705     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30038705 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2018 ; 9 (51 ): 29574-29586 Nephropedia Template TP {{tp|p=30038705 |t=2018. Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer |pdf=|usr=}}{{30038705 }} gab.com Text Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30038705 #FOAvip BACKGROUND: Tumor microenvironment including fibrosis has a pivotal role in cancer growth and distant metastasis. Fibrosis is a known risk factor for carcinogenesis, but its biological role in disease invasion and metastasis in colorectal cancer (CRC) remains unclear. In particular, there is no report on how fibrosis of metastatic lymph nodes (MLNs) in CRC contributes to prognosis. METHODS: We reviewed 94 colorectal adenocarcinoma patients with MLNs who underwent colectomy. Both the primary tumors and MLNs were analyzed for alpha-smooth muscle actin (?-SMA) expression and collagen deposition. RESULTS: Higher ?-SMA expression and collagen deposition in MLNs were associated with significantly shorter relapse-free survival and overall survival in CRC patients. ?-SMA expression in MLNs (HR, 1.53; p = 0.034) was independent predictive factor of overall survival in multivariate Cox proportional hazards regression analysis of clinicopathological factors. In the Stage III patient subgroup, ?-SMA expression in MLNs was a strong prognostic marker (HR, 3.01; p = 0.006). On the other hand, higher ?-SMA expression and collagen deposition in primary tumors were associated with short overall survival, but they were not significant factors in multivariate Cox regression analyses. In MLNs, the podoplanin signals co-localized with ?-SMA expression and were confirmed by the dual immunofluorescence staining, implying that the MLN stromal cells were fibroblastic reticular cells. CONCLUSION: Both high collagen deposition and high ?-SMA expression in MLNs predicted poor prognosis in CRC. Twit Text FOAVip Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30038705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30038705 #FOAvip English Wikipedia <ref>{{Cite pmid|30038705 }}</ref> Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer #MMPMID30038705 Ikuta D ; Miyake T ; Shimizu T ; Sonoda H ; Mukaisho KI ; Tokuda A ; Ueki T ; Sugihara H ; Tani M Oncotarget 2018[Jul]; 9 (51 ): 29574-29586 PMID30038705 show ga BACKGROUND: Tumor microenvironment including fibrosis has a pivotal role in cancer growth and distant metastasis. Fibrosis is a known risk factor for carcinogenesis, but its biological role in disease invasion and metastasis in colorectal cancer (CRC) remains unclear. In particular, there is no report on how fibrosis of metastatic lymph nodes (MLNs) in CRC contributes to prognosis. METHODS: We reviewed 94 colorectal adenocarcinoma patients with MLNs who underwent colectomy. Both the primary tumors and MLNs were analyzed for alpha-smooth muscle actin (?-SMA) expression and collagen deposition. RESULTS: Higher ?-SMA expression and collagen deposition in MLNs were associated with significantly shorter relapse-free survival and overall survival in CRC patients. ?-SMA expression in MLNs (HR, 1.53; p = 0.034) was independent predictive factor of overall survival in multivariate Cox proportional hazards regression analysis of clinicopathological factors. In the Stage III patient subgroup, ?-SMA expression in MLNs was a strong prognostic marker (HR, 3.01; p = 0.006). On the other hand, higher ?-SMA expression and collagen deposition in primary tumors were associated with short overall survival, but they were not significant factors in multivariate Cox regression analyses. In MLNs, the podoplanin signals co-localized with ?-SMA expression and were confirmed by the dual immunofluorescence staining, implying that the MLN stromal cells were fibroblastic reticular cells. CONCLUSION: Both high collagen deposition and high ?-SMA expression in MLNs predicted poor prognosis in CRC. äFibrosis in metastatic lymph nodes is clinically correlated to poor pr(epmc).pdf DeepDyve Pubget Overpricing