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10.1038/s41590-017-0032-8 http://scihub22266oqcxt.onion/10.1038/s41590-017-0032-8 C6049828!6049828!29335648     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2018 ; 19 (2): 162-72 Nephropedia Template TP {{tp|p=29335648|t=2018. Rapid chromatin repression by Aire provides precise control of immune tolerance |pdf=|usr=}}{{29335648}} gab.com Text Rapid chromatin repression by Aire provides precise control of immune tolerance JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29335648 #FOAvip Aire mediates the expression of tissue-specific antigens in thymic epithelial cells to remove dangerous self-reactive T lymphocytes. However, the mechanism that allows expression of tissue-specific genes at levels that prevent harm is unknown. Here we show that Brg1 generates accessibility at tissue-specific loci to impose central tolerance. We found that Aire harbors an intrinsic repressive function that restricts chromatin accessibility and opposes Brg1 across the genome. Aire exerted this repressive influence within minutes upon recruitment to chromatin and restrained the amplitude of active transcription. Autoimmune mutations that impair Aire-induced activation also impair the its repression function, indicating dual roles for Aire. Together, Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity, yet promote immune tolerance. Twit Text FOAVip Rapid chromatin repression by Aire provides precise control of immune tolerance ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29335648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29335648 #FOAvip English Wikipedia <ref>{{Cite pmid|29335648}}</ref> Rapid chromatin repression by Aire provides precise control of immune tolerance #MMPMID29335648 Koh AS; Miller EL; Buenrostro JD; Moskowitz DM; Wang J; Greenleaf WJ; Chang HY; Crabtree GR Nat Immunol 2018[Feb]; 19 (2): 162-72 PMID29335648show ga Aire mediates the expression of tissue-specific antigens in thymic epithelial cells to remove dangerous self-reactive T lymphocytes. However, the mechanism that allows expression of tissue-specific genes at levels that prevent harm is unknown. Here we show that Brg1 generates accessibility at tissue-specific loci to impose central tolerance. We found that Aire harbors an intrinsic repressive function that restricts chromatin accessibility and opposes Brg1 across the genome. Aire exerted this repressive influence within minutes upon recruitment to chromatin and restrained the amplitude of active transcription. Autoimmune mutations that impair Aire-induced activation also impair the its repression function, indicating dual roles for Aire. Together, Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity, yet promote immune tolerance. äRapid chromatin repression by Aire provides precise control of immune (epmc).pdf DeepDyve Pubget Overpricing