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10.1016/j.immuni.2018.02.012 http://scihub22266oqcxt.onion/10.1016/j.immuni.2018.02.012 C6049611!6049611!29523440     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2018 ; 48 (3): 542-555.e6 Nephropedia Template TP {{tp|p=29523440|t=2018. Mitochondria?ER contact sites are immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells |pdf=|usr=}}{{29523440}} gab.com Text Mitochondria ER contact sites are immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=29523440 #FOAvip Glycolysis is linked to the rapid recall capacity of memory CD8+ T cells, but the pathways that glucose fuels and the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are not known. We found that mitochondria?ER contact sites are immunometabolic hubs that integrate mTORC2-initiated signaling with glucose metabolism and mitochondrial respiration in memory CD8+ T cells. Specifically, in this subcellular compartment, mTORC2, Akt and Gsk-3? were present by default. Rapid activation of Akt by mTORC2 led to inhibition of Gsk-3? at mitochondria?ER junctions, enabling recruitment of hexokinase I (HK-I) to the mitochondrial channel, VDAC. Binding of HK-I to VDAC promoted cellular respiration by facilitating metabolite flux into mitochondria. Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of IFN-? in memory T cells. Subcellular organization of key signaling events enabling HK-I recruitment to VDAC thus underpins the metabolic reprogramming needed for memory CD8+ T cells to rapidly acquire effector function. Twit Text FOAVip Mitochondria ER contact sites are immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=29523440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29523440 #FOAvip English Wikipedia <ref>{{Cite pmid|29523440}}</ref> Mitochondria?ER contact sites are immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells #MMPMID29523440 Bantug GR; Fischer MG; Grählert J; Balmer ML; Unterstab G; Develioglu L; Steiner R; Zhang L; da Costa ASH; Gubser PM; Burgener AV; Sauder U; Löliger J; Belle R; Dimeloe S; Lötscher J; Jauch A; Recher M; Hönger G; Hall MN; Romero P; Frezza C; Hess C Immunity 2018[Mar]; 48 (3): 542-555.e6 PMID29523440show ga Glycolysis is linked to the rapid recall capacity of memory CD8+ T cells, but the pathways that glucose fuels and the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are not known. We found that mitochondria?ER contact sites are immunometabolic hubs that integrate mTORC2-initiated signaling with glucose metabolism and mitochondrial respiration in memory CD8+ T cells. Specifically, in this subcellular compartment, mTORC2, Akt and Gsk-3? were present by default. Rapid activation of Akt by mTORC2 led to inhibition of Gsk-3? at mitochondria?ER junctions, enabling recruitment of hexokinase I (HK-I) to the mitochondrial channel, VDAC. Binding of HK-I to VDAC promoted cellular respiration by facilitating metabolite flux into mitochondria. Glucose tracing pinpointed pyruvate oxidation in mitochondria, which was the metabolic requirement for rapid generation of IFN-? in memory T cells. Subcellular organization of key signaling events enabling HK-I recruitment to VDAC thus underpins the metabolic reprogramming needed for memory CD8+ T cells to rapidly acquire effector function. äMitochondria?ER contact sites are immunometabolic hubs that orchestrat(epmc).pdf DeepDyve Pubget Overpricing