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10.1016/j.jsb.2016.05.003

http://scihub22266oqcxt.onion/10.1016/j.jsb.2016.05.003
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C6049083!6049083!27181417
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suck abstract from ncbi

pmid27181417      J+Struct+Biol 2016 ; 196 (1): 15-9
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  • Organelle remodeling at membrane contact sites #MMPMID27181417
  • Henne WM
  • J Struct Biol 2016[Oct]; 196 (1): 15-9 PMID27181417show ga
  • Cellular organelles must execute sophisticated biological processes to persist, and often communicate with one another to exchange metabolites and information. Recent studies suggest inter-organelle membrane contact sites (MCSs) are hubs for this cellular cross-talk. MCSs also govern membrane remodeling, thus controlling aspects of organelle shape, identity, and function. Here, we summarize three emerging phenomena that MCSs appear to govern: 1) organelle identity via the non-vesicular exchange of lipids, 2) mitochondrial shape and division, and 3) endosomal migration in response to sterol trafficking. We also discuss the role for ER-endolysosomal contact sites in cholesterol metabolism, and the potential biomedical importance this holds. Indeed, the emerging field inter-organellar cross-talk promises substantial advances in the fields of lipid metabolism and cell signaling.
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