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2018 ; 9
(ä): 1592
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Getting in and Staying Alive: Role for Coronin 1 in the Survival of Pathogenic
Mycobacteria and Naïve T Cells
#MMPMID30042765
Mori M
; Pieters J
Front Immunol
2018[]; 9
(ä): 1592
PMID30042765
show ga
There are many different pathogenic stimuli that are able to activate the immune
system, ranging from microbes that include bacteria, viruses, fungi, and
parasites to host-derived triggers such as autoantigens that can induce
autoimmunity as well as neoantigens involved in tumorigenesis. One of the key
interactions shaping immunity toward these triggers involves the encounter of
antigen-processing and -presenting cells such as macrophages and dendritic cells
with T cells, resulting in immune responses that are highly selective for the
antigenic trigger. Research over the past few years has implicated members of the
coronin protein family, in particular coronin 1, in responses against several
pathogenic triggers. While coronin 1 was initially described as a host factor
allowing the intracellular survival of the pathogen Mycobacterium tuberculosis,
subsequent work showed it to be a crucial factor for naïve T cell homeostasis.
The activity of coronin 1 in allowing the intracellular survival of pathogenic
mycobacteria is relatively well characterized, involving the activation of the
Ca(2+)/calcineurin pathway, while coronin 1's role in modulating naïve T cell
homeostasis remains more enigmatic. In this mini review, we discuss the knowledge
on the role for coronin 1 in immune cell functioning and provide a number of
potential scenarios via which coronin 1 may be able to regulate naïve T cell
homeostasis.