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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancer+Manag+Res
2018 ; 10
(ä): 2003-2018
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Evidence-based complementary treatment of pancreatic cancer: a review of adjunct
therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C,
statins, metformin, curcumin, and aspirin
#MMPMID30034255
Bigelsen S
Cancer Manag Res
2018[]; 10
(ä): 2003-2018
PMID30034255
show ga
Despite new and exciting research and renewed optimism about future therapy,
current statistics of survival from pancreatic cancer remains dismal. Patients
seeking alternative or complementary treatments should be warned to avoid the
hype and instead look to real science. A variety of relatively safe and
inexpensive treatment options that have shown success in preclinical models
and/or retrospective studies are currently available. Patients require their
physicians to provide therapeutic guidance and assistance in obtaining and
administrating these various therapies. Paricalcitol, an analog of vitamin D, has
been shown by researchers at the Salk Institute for Biological Studies to break
though the protective stroma surrounding tumor cells. Hydroxychloroquine has been
shown to inhibit autophagy, a process by which dying cells recycle injured
organelles and internal toxins to generate needed energy for survival and
reproduction. Intravenous vitamin C creates a toxic accumulation of hydrogen
peroxide within cancer cells, hastening their death. Metformin inhibits
mitochondrial oxidative metabolism utilized by cancer stem cells. Statins inhibit
not only cholesterol but also other factors in the same pathway that affect
cancer cell growth, protein synthesis, and cell cycle progression. A novel
formulation of curcumin may prevent resistance to chemotherapy and inhibit
pancreatic cancer cell proliferation. Aspirin therapy has been shown to prevent
pancreatic cancer and may be useful to prevent recurrence. These therapies are
all currently available and are reviewed in this paper with emphasis on the most
recent laboratory research and clinical studies.