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2018 ; 31
(8
): 902-909
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English Wikipedia
Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in
Obese Rats on a High-Salt Diet
#MMPMID29722788
Maheshwari M
; Romero CA
; Monu SR
; Kumar N
; Liao TD
; Peterson EL
; Carretero OA
Am J Hypertens
2018[Jul]; 31
(8
): 902-909
PMID29722788
show ga
BACKGROUND: Obesity is a public health problem, associated with salt sensitive
hypertension, kidney inflammation, and fibrosis.
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with
anti-inflammatory and anti-fibrotic properties. However, its effect on preventing
kidney damage in obesity is unknown. We hypothesized that Zucker obese (ZO) rats
on a high-salt (HS) diet develop renal damage, inflammation, fibrosis, and this
is prevented with Ac-SDKP treatment. METHODS: Zucker lean (ZL) and ZO rats (8
weeks old) were treated with Ac-SDKP (1.6 mg/kg/day) while maintained on either a
normal-salt (NS; 0.4%) or HS (4%) diet for 8 weeks. Systolic blood pressure
(SBP), albuminuria, renal inflammation, and fibrosis were evaluated. RESULTS: HS
diet increased macrophage infiltration in the kidneys of both ZL and ZO rats but
was significantly higher in ZO rats receiving the HS diet (ZL + NS, 13.9 ± 1.3
vs. ZL + HS, 19.14 ± 1.5 and ZO + NS, 25.5 ± 1.4 vs. ZO + HS, 87.8 ± 10.8
cells/mm2; P < 0.05). Ac-SDKP prevented macrophage infiltration in ZO rats (ZO +
HS + Ac-SDKP, 32.18 ± 2.4 cells/mm2; P < 0.05). Similarly, glomerulosclerosis,
cortical, and medullary interstitial fibrosis were increased in ZO rats fed the
HS diet, and Ac-SDKP attenuated these alterations (P < 0.05). SBP was increased
in ZO rats fed the HS diet (ZO + NS, 121.3 ± 8.9 vs. ZO + HS, 164 ± 6.9 mm Hg; P
< 0.05), and it was significantly decreased with Ac-SDKP treatment (ZO + HS +
Ac-SDKP, 144.05 ± 14.1 mm Hg; P = 0.004). Albuminuria was higher in ZO rats than
in ZL rats; however, neither HS nor Ac-SDKP treatment affected it. CONCLUSIONS:
Ac-SDKP treatment in ZO rats fed a HS diet prevented renal damage by reducing
inflammation, fibrosis, and SBP.
|*Sodium Chloride, Dietary
[MESH]
|Albuminuria/etiology/physiopathology/prevention & control
[MESH]
|Animals
[MESH]
|Anti-Inflammatory Agents/*pharmacology
[MESH]
|Antihypertensive Agents/*pharmacology
[MESH]
|Blood Pressure/drug effects
[MESH]
|Disease Models, Animal
[MESH]
|Fibrosis
[MESH]
|Glomerulonephritis/etiology/pathology/physiopathology/*prevention & control
[MESH]
|Hypertension/etiology/physiopathology/*prevention & control
[MESH]