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10.1038/nm.4350 http://scihub22266oqcxt.onion/10.1038/nm.4350 C6048953!6048953!28697184     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2017 ; 23 (7): 804-14 Nephropedia Template TP {{tp|p=28697184|t=2017. Insulin action and resistance in obesity and type 2 diabetes |pdf=|usr=}}{{28697184}} gab.com Text Insulin action and resistance in obesity and type 2 diabetes JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=28697184 #FOAvip Nutritional excess is a major forerunner of type 2 diabetes and enhances the secretion of insulin but attenuates its metabolic actions in the liver, skeletal muscle and adipose tissue. However, conflicting evidence indicates a lack of knowledge of the timing of these events during the development of obesity and diabetes and is a key gap in our understanding of metabolic disease. This Perspective reviews alternate viewpoints and recent results on the temporal and mechanistic connections between hyperinsulinemia, obesity and insulin resistance. Although much attention has addressed early steps in the insulin signaling cascade, insulin resistance in obesity appears to be largely elicited downstream of these steps. New findings also connect insulin resistance to extensive metabolic crosstalk between liver, adipose, pancreas and skeletal muscle. These and other advances over the last 5 years offer both exciting opportunities and daunting challenges in developing new therapeutic strategies for the treatment of type 2 diabetes. Twit Text FOAVip Insulin action and resistance in obesity and type 2 diabetes ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=28697184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28697184 #FOAvip English Wikipedia <ref>{{Cite pmid|28697184}}</ref> Insulin action and resistance in obesity and type 2 diabetes #MMPMID28697184 Czech MP Nat Med 2017[Jul]; 23 (7): 804-14 PMID28697184show ga Nutritional excess is a major forerunner of type 2 diabetes and enhances the secretion of insulin but attenuates its metabolic actions in the liver, skeletal muscle and adipose tissue. However, conflicting evidence indicates a lack of knowledge of the timing of these events during the development of obesity and diabetes and is a key gap in our understanding of metabolic disease. This Perspective reviews alternate viewpoints and recent results on the temporal and mechanistic connections between hyperinsulinemia, obesity and insulin resistance. Although much attention has addressed early steps in the insulin signaling cascade, insulin resistance in obesity appears to be largely elicited downstream of these steps. New findings also connect insulin resistance to extensive metabolic crosstalk between liver, adipose, pancreas and skeletal muscle. These and other advances over the last 5 years offer both exciting opportunities and daunting challenges in developing new therapeutic strategies for the treatment of type 2 diabetes. äInsulin action and resistance in obesity and type 2 diabetes (epmc).pdf DeepDyve Pubget Overpricing