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10.1073/pnas.1722317115 http://scihub22266oqcxt.onion/10.1073/pnas.1722317115 C6048499!6048499!29941602     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (28): E6467-76 Nephropedia Template TP {{tp|p=29941602|t=2018. Targeting ?1-integrin inhibits vascular leakage in endotoxemia |pdf=|usr=}}{{29941602}} gab.com Text Targeting 1-integrin inhibits vascular leakage in endotoxemia JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29941602 #FOAvip Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking. Here, we show that targeting ?1-integrin in vivo with inhibitory antibodies or deletion of a single allele of endothelial ?1-integrin inhibits lipopolysaccharide (LPS)-induced vascular leakage in murine endotoxemia. The inflammatory agents IL-1?, thrombin, and LPS induced changes in endothelial cell?extracellular matrix (ECM) adhesion via ?1-integrin, angiopoietin-2, and the adapter protein tensin-1, leading to increased endothelial cell contractility and permeability. These results indicate that ?1-integrin actively promotes vascular leakage and that targeting ?1-integrin signaling could be a novel means of achieving vascular stabilization in pathological vascular leak. Twit Text FOAVip Targeting 1-integrin inhibits vascular leakage in endotoxemia ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29941602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29941602 #FOAvip English Wikipedia <ref>{{Cite pmid|29941602}}</ref> Targeting ?1-integrin inhibits vascular leakage in endotoxemia #MMPMID29941602 Hakanpaa L; Kiss EA; Jacquemet G; Miinalainen I; Lerche M; Guzmán C; Mervaala E; Eklund L; Ivaska J; Saharinen P Proc Natl Acad Sci U S A 2018[Jul]; 115 (28): E6467-76 PMID29941602show ga Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking. Here, we show that targeting ?1-integrin in vivo with inhibitory antibodies or deletion of a single allele of endothelial ?1-integrin inhibits lipopolysaccharide (LPS)-induced vascular leakage in murine endotoxemia. The inflammatory agents IL-1?, thrombin, and LPS induced changes in endothelial cell?extracellular matrix (ECM) adhesion via ?1-integrin, angiopoietin-2, and the adapter protein tensin-1, leading to increased endothelial cell contractility and permeability. These results indicate that ?1-integrin actively promotes vascular leakage and that targeting ?1-integrin signaling could be a novel means of achieving vascular stabilization in pathological vascular leak. äTargeting ?1-integrin inhibits vascular leakage in endotoxemia (epmc).pdf DeepDyve Pubget Overpricing