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http://scihub22266oqcxt.onion/ C6048405!6048405!30034934     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cancer+Res 2018 ; 8 (6): 955-63 Nephropedia Template TP {{tp|p=30034934|t=2018. Pregnancy-associated plasma protein a in cancer: expression, oncogenic functions and regulation |pdf=|usr=}}{{30034934}} gab.com Text Pregnancy-associated plasma protein a in cancer: expression, oncogenic functions and regulation JO: Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=30034934 #FOAvip Pregnancy-associated plasma protein A (PAPPA) is a protease that plays important roles in pregnancy, but interestingly acts as an oncogene outside of pregnancy. This review summarizes the oncogenic roles of PAPPA, including its expression levels in multiple malignancies, regulatory and signaling interactions, and pro-tumor functions, which include promoting tumor cell proliferation, invasion, migration and metastasis. These PAPPA activities are linked to IGFBP-4 proteolysis, increased IFG bioavailability, and activation of the NF-?B, PI3K/AKT and ERK signaling pathways. Therefore, PAPPA could be used as a biomarker for monitoring cancer development and progression as well as a potential therapeutic target. Twit Text FOAVip Pregnancy-associated plasma protein a in cancer: expression, oncogenic functions and regulation ????Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=30034934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30034934 #FOAvip English Wikipedia <ref>{{Cite pmid|30034934}}</ref> Pregnancy-associated plasma protein a in cancer: expression, oncogenic functions and regulation #MMPMID30034934 Guo Y; Bao Y; Guo D; Yang W Am J Cancer Res 2018[]; 8 (6): 955-63 PMID30034934show ga Pregnancy-associated plasma protein A (PAPPA) is a protease that plays important roles in pregnancy, but interestingly acts as an oncogene outside of pregnancy. This review summarizes the oncogenic roles of PAPPA, including its expression levels in multiple malignancies, regulatory and signaling interactions, and pro-tumor functions, which include promoting tumor cell proliferation, invasion, migration and metastasis. These PAPPA activities are linked to IGFBP-4 proteolysis, increased IFG bioavailability, and activation of the NF-?B, PI3K/AKT and ERK signaling pathways. Therefore, PAPPA could be used as a biomarker for monitoring cancer development and progression as well as a potential therapeutic target. äPregnancy-associated plasma protein a in cancer: expression, oncogenic(epmc).pdf DeepDyve Pubget Overpricing