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10.2176/nmc.ra.2018-0022 http://scihub22266oqcxt.onion/10.2176/nmc.ra.2018-0022 C6048350!6048350!29848906     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurol+Med+Chir+(Tokyo) 2018 ; 58 (7): 303-10 Nephropedia Template TP {{tp|p=29848906|t=2018. Elevation of Autoantibody in Patients with Ischemic Stroke |pdf=|usr=}}{{29848906}} gab.com Text Elevation of Autoantibody in Patients with Ischemic Stroke JO: Neurol Med Chir (Tokyo) http://www.kidney.de/pget.php?&tw=1&pmid=29848906 #FOAvip Recent clinical research has revealed a significant correlation between atherosclerosis, one of the primary etiologies of ischemic stroke, and the immune system. Assuming that ?disease-specific autoantibodies are produced in the sera of patients with ischemic stroke,? we investigated multiple arteriosclerosis-related antibodies using the serological identification of antigens by recombinant cDNA expression cloning (SEREX), an established method for identifying antigenic proteins. We either screened a human aortic endothelial cell cDNA library or conducted protein array screening using the sera from patients with ischemic stroke, such as carotid artery stenosis or transient ischemic attack (TIA). Next, we measured serum antibody levels using amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) in patient/healthy donor (HD) cohorts and identified several antigens, the antibody levels of which were significantly higher in patients with ischemic stroke than in HDs. This review introduced the method of identifying antigens by the SEREX and protein microarray and summarized antigenic proteins. In particular, it focused on anti-replication protein A2 antibody and anti-programmed cell death 11 antibody, which are significantly related to atherosclerotic plaque and ischemic brain tissue, respectively, and proposed the mechanism of elevated autoantibody levels against them. Furthermore, this review suggests a possibility of clinical application as an atherosclerotic disease diagnostic marker for TIA or cerebral infarction. Twit Text FOAVip Elevation of Autoantibody in Patients with Ischemic Stroke ????Neurol Med Chir (Tokyo) http://www.kidney.de/pget.php?&tw=1&pmid=29848906 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29848906 #FOAvip English Wikipedia <ref>{{Cite pmid|29848906}}</ref> Elevation of Autoantibody in Patients with Ischemic Stroke #MMPMID29848906 YOSHIDA Y; HIWASA T; MACHIDA T; KOBAYASHI E; MINE S; MATSUSHIMA J; TAKIGUCHI M; IWADATE Y Neurol Med Chir (Tokyo) 2018[Jul]; 58 (7): 303-10 PMID29848906show ga Recent clinical research has revealed a significant correlation between atherosclerosis, one of the primary etiologies of ischemic stroke, and the immune system. Assuming that ?disease-specific autoantibodies are produced in the sera of patients with ischemic stroke,? we investigated multiple arteriosclerosis-related antibodies using the serological identification of antigens by recombinant cDNA expression cloning (SEREX), an established method for identifying antigenic proteins. We either screened a human aortic endothelial cell cDNA library or conducted protein array screening using the sera from patients with ischemic stroke, such as carotid artery stenosis or transient ischemic attack (TIA). Next, we measured serum antibody levels using amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) in patient/healthy donor (HD) cohorts and identified several antigens, the antibody levels of which were significantly higher in patients with ischemic stroke than in HDs. This review introduced the method of identifying antigens by the SEREX and protein microarray and summarized antigenic proteins. In particular, it focused on anti-replication protein A2 antibody and anti-programmed cell death 11 antibody, which are significantly related to atherosclerotic plaque and ischemic brain tissue, respectively, and proposed the mechanism of elevated autoantibody levels against them. Furthermore, this review suggests a possibility of clinical application as an atherosclerotic disease diagnostic marker for TIA or cerebral infarction. äElevation of Autoantibody in Patients with Ischemic Stroke (epmc).pdf DeepDyve Pubget Overpricing