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10.18240/ijo.2018.07.08 http://scihub22266oqcxt.onion/10.18240/ijo.2018.07.08 C6048344!6048344 !30046527     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30046527 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Ophthalmol 2018 ; 11 (7 ): 1120-1128 Nephropedia Template TP {{tp|p=30046527 |t=2018. GSK3? inhibits epithelial-mesenchymal transition via the Wnt/?-catenin and PI3K/Akt pathways |pdf=|usr=}}{{30046527 }} gab.com Text GSK3 inhibits epithelial-mesenchymal transition via the Wnt/ -catenin and PI3K/Akt pathways JO: Int J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=30046527 #FOAvip AIM: To investigate the regulatory mechanism of glycogen synthase kinase 3? (GSK3?) in epithelial-mesenchymal transition (EMT) process after proliferative vitreoretinopathy (PVR) induction. METHODS: Experimental PVR was induced by intravitreal injection of retinal pigment epithelium (RPE) cells in the eyes of rabbits. A PI3K/Akt inhibitor (wortmannin) and a GSK3? inhibitor (LiCl) were also injected at different time during PVR progress. Electroretinogram (ERG), ocular fundus photographs, and B-scan ultrasonography were used to observe the PVR progress. Western blot test on the extracted retina were performed at 1, 2, 4wk. The expression of the mesenchymal marker vimentin was determined by immunohistochemistry. Toxicity of wortmannin and LiCl were evaluated by ERG and TdT-mediated dUTP nick-end labeling (TUNEL) assay. The vitreous was also collected for metabolomic analysis. RESULTS: Experimental PVR could significantly lead to EMT, along with the suppressed expression of GSK3? and the activation of Wnt/?-catenin and PI3K/Akt pathways. It was verified that upregulating the expression of GSK3? could effectively inhibit EMT process by suppressing Wnt/?-catenin and PI3K/Akt pathways. CONCLUSION: GSK3? effectively inhibits EMT via the Wnt/?-catenin and PI3K/Akt pathways. GSK3? may be regarded as a promising target of experimental PVR inhibition. Twit Text FOAVip GSK3 inhibits epithelial-mesenchymal transition via the Wnt/ -catenin and PI3K/Akt pathways ????Int J Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=30046527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30046527 #FOAvip English Wikipedia <ref>{{Cite pmid|30046527 }}</ref> GSK3? inhibits epithelial-mesenchymal transition via the Wnt/?-catenin and PI3K/Akt pathways #MMPMID30046527 Zhang C ; Su L ; Huang L ; Song ZY Int J Ophthalmol 2018[]; 11 (7 ): 1120-1128 PMID30046527 show ga AIM: To investigate the regulatory mechanism of glycogen synthase kinase 3? (GSK3?) in epithelial-mesenchymal transition (EMT) process after proliferative vitreoretinopathy (PVR) induction. METHODS: Experimental PVR was induced by intravitreal injection of retinal pigment epithelium (RPE) cells in the eyes of rabbits. A PI3K/Akt inhibitor (wortmannin) and a GSK3? inhibitor (LiCl) were also injected at different time during PVR progress. Electroretinogram (ERG), ocular fundus photographs, and B-scan ultrasonography were used to observe the PVR progress. Western blot test on the extracted retina were performed at 1, 2, 4wk. The expression of the mesenchymal marker vimentin was determined by immunohistochemistry. Toxicity of wortmannin and LiCl were evaluated by ERG and TdT-mediated dUTP nick-end labeling (TUNEL) assay. The vitreous was also collected for metabolomic analysis. RESULTS: Experimental PVR could significantly lead to EMT, along with the suppressed expression of GSK3? and the activation of Wnt/?-catenin and PI3K/Akt pathways. It was verified that upregulating the expression of GSK3? could effectively inhibit EMT process by suppressing Wnt/?-catenin and PI3K/Akt pathways. CONCLUSION: GSK3? effectively inhibits EMT via the Wnt/?-catenin and PI3K/Akt pathways. GSK3? may be regarded as a promising target of experimental PVR inhibition. äGSK3? inhibits epithelial-mesenchymal transition via the Wnt/?-catenin(epmc).pdf DeepDyve Pubget Overpricing