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10.3389/fimmu.2018.01593

http://scihub22266oqcxt.onion/10.3389/fimmu.2018.01593
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C6048227!6048227!30042766
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suck abstract from ncbi


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pmid30042766      Front+Immunol 2018 ; 9 (ä): ä
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  • CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions #MMPMID30042766
  • Amici SA; Young NA; Narvaez-Miranda J; Jablonski KA; Arcos J; Rosas L; Papenfuss TL; Torrelles JB; Jarjour WN; Guerau-de-Arellano M
  • Front Immunol 2018[]; 9 (ä): ä PMID30042766show ga
  • Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there are few markers that allow for robust dissection of macrophage phenotype. We recently identified CD38 as a marker of inflammatory macrophages in murine in vitro and in vivo models. However, it is unknown whether CD38 plays a similar marker and/or functional role in human macrophages and inflammatory diseases. Here, we establish that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-?) inflammatory stimuli, but not with the alternative stimulus, IL-4. Pharmacologic and/or genetic CD38 loss-of-function significantly reduced the secretion of inflammatory cytokines IL-6 and IL-12p40 and glycolytic activity in human primary macrophages. Finally, monocyte analyses in systemic lupus erythematosus patients revealed that, while all monocytes express CD38, high CD38 expression in the non-classical monocyte subpopulation is associated with disease. These data are consistent with an inflammatory marker role for CD38 in human macrophages and monocytes.
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