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10.1038/s41467-018-05196-3 http://scihub22266oqcxt.onion/10.1038/s41467-018-05196-3 C6048122!6048122!30013024     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30013024|t=2018. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b |pdf=|usr=}}{{30013024}} gab.com Text Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013024 #FOAvip Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to the production of pathogenic autoantibodies and the development of autoimmunity. Here we show that miR-146a controls GC responses by targeting multiple CD40 signaling pathway components in B cells; by contrast, loss of miR-146a in T cells does not alter humoral responses. However, specific deletion of both miR-146a and its paralog, miR-146b, in T cells increases Tfh cell numbers and enhanced GC reactions. Thus, our data reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b. Together, members of the miR-146 family serve as crucial molecular brakes to coordinately control GC reactions to generate protective humoral responses without eliciting unwanted autoimmunity. Twit Text FOAVip Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013024 #FOAvip English Wikipedia <ref>{{Cite pmid|30013024}}</ref> Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b #MMPMID30013024 Cho S; Lee HM; Yu IS; Choi YS; Huang HY; Hashemifar SS; Lin LL; Chen MC; Afanasiev ND; Khan AA; Lin SW; Rudensky AY; Crotty S; Lu LF Nat Commun 2018[]; 9 (ä): ä PMID30013024show ga Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to the production of pathogenic autoantibodies and the development of autoimmunity. Here we show that miR-146a controls GC responses by targeting multiple CD40 signaling pathway components in B cells; by contrast, loss of miR-146a in T cells does not alter humoral responses. However, specific deletion of both miR-146a and its paralog, miR-146b, in T cells increases Tfh cell numbers and enhanced GC reactions. Thus, our data reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b. Together, members of the miR-146 family serve as crucial molecular brakes to coordinately control GC reactions to generate protective humoral responses without eliciting unwanted autoimmunity. äDifferential cell-intrinsic regulations of germinal center B and T cel(epmc).pdf DeepDyve Pubget Overpricing