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10.1038/s41467-018-04974-3 http://scihub22266oqcxt.onion/10.1038/s41467-018-04974-3 C6048100!6048100!30013031     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30013031|t=2018. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |pdf=|usr=}}{{30013031}} gab.com Text Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013031 #FOAvip Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren?s-like diseases. Here, we show that Act1 functions as a negative regulator in T and B cells via direct inhibition of STAT3. Mass spectrometry analysis detected an Act1?STAT3 complex, deficiency of Act1 (but not Il17ra-, Il17rc-, or Il17rb) results in hyper IL-23- and IL-21-induced STAT3 activation in T and B cells, respectively. IL-23R deletion or blockade of IL-21 ameliorates SLE- and Sjögren?s-like diseases in Act1?/? mice. Act1 deficiency results in hyperactivated follicular Th17 cells with elevated IL-21 expression, which promotes T?B cell interaction for B cell expansion and antibody production. Moreover, anti-IL-21 ameliorates the SLE- and Sjögren?s-like diseases in Act1-deficient mice. Thus, IL-21 blocking antibody might be an effective therapy for treating SLE- and Sjögren?s-like syndrome in patients containing Act1 mutation. Twit Text FOAVip Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013031 #FOAvip English Wikipedia <ref>{{Cite pmid|30013031}}</ref> Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 #MMPMID30013031 Zhang CJ; Wang C; Jiang M; Gu C; Xiao J; Chen X; Martin BN; Tang F; Yamamoto E; Xian Y; Wang H; Li F; Sartor RB; Smith H; Husni ME; Shi FD; Gao J; Carman J; Dongre A; McKarns SC; Coppieters K; Jørgensen TN; Leonard WJ; Li X Nat Commun 2018[]; 9 (ä): ä PMID30013031show ga Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren?s-like diseases. Here, we show that Act1 functions as a negative regulator in T and B cells via direct inhibition of STAT3. Mass spectrometry analysis detected an Act1?STAT3 complex, deficiency of Act1 (but not Il17ra-, Il17rc-, or Il17rb) results in hyper IL-23- and IL-21-induced STAT3 activation in T and B cells, respectively. IL-23R deletion or blockade of IL-21 ameliorates SLE- and Sjögren?s-like diseases in Act1?/? mice. Act1 deficiency results in hyperactivated follicular Th17 cells with elevated IL-21 expression, which promotes T?B cell interaction for B cell expansion and antibody production. Moreover, anti-IL-21 ameliorates the SLE- and Sjögren?s-like diseases in Act1-deficient mice. Thus, IL-21 blocking antibody might be an effective therapy for treating SLE- and Sjögren?s-like syndrome in patients containing Act1 mutation. äAct1 is a negative regulator in T and B cells via direct inhibition of(epmc).pdf DeepDyve Pubget Overpricing