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10.1038/s41467-018-05044-4 http://scihub22266oqcxt.onion/10.1038/s41467-018-05044-4 C6048065!6048065!30013029     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30013029|t=2018. Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission |pdf=|usr=}}{{30013029}} gab.com Text Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013029 #FOAvip Sustained clinical remission (CR) without drug treatment has not been achieved in patients with rheumatoid arthritis (RA). This implies a substantial difference between CR and the healthy state, but it has yet to be quantified. We report a longitudinal monitoring of the drug response at multi-omics levels in the peripheral blood of patients with RA. Our data reveal that drug treatments alter the molecular profile closer to that of HCs at the transcriptome, serum proteome, and immunophenotype level. Patient follow-up suggests that the molecular profile after drug treatments is associated with long-term stable CR. In addition, we identify molecular signatures that are resistant to drug treatments. These signatures are associated with RA independently of known disease severity indexes and are largely explained by the imbalance of neutrophils, monocytes, and lymphocytes. This high-dimensional phenotyping provides a quantitative measure of molecular remission and illustrates a multi-omics approach to understanding drug response. Twit Text FOAVip Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013029 #FOAvip English Wikipedia <ref>{{Cite pmid|30013029}}</ref> Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission #MMPMID30013029 Tasaki S; Suzuki K; Kassai Y; Takeshita M; Murota A; Kondo Y; Ando T; Nakayama Y; Okuzono Y; Takiguchi M; Kurisu R; Miyazaki T; Yoshimoto K; Yasuoka H; Yamaoka K; Morita R; Yoshimura A; Toyoshiba H; Takeuchi T Nat Commun 2018[]; 9 (ä): ä PMID30013029show ga Sustained clinical remission (CR) without drug treatment has not been achieved in patients with rheumatoid arthritis (RA). This implies a substantial difference between CR and the healthy state, but it has yet to be quantified. We report a longitudinal monitoring of the drug response at multi-omics levels in the peripheral blood of patients with RA. Our data reveal that drug treatments alter the molecular profile closer to that of HCs at the transcriptome, serum proteome, and immunophenotype level. Patient follow-up suggests that the molecular profile after drug treatments is associated with long-term stable CR. In addition, we identify molecular signatures that are resistant to drug treatments. These signatures are associated with RA independently of known disease severity indexes and are largely explained by the imbalance of neutrophils, monocytes, and lymphocytes. This high-dimensional phenotyping provides a quantitative measure of molecular remission and illustrates a multi-omics approach to understanding drug response. äMulti-omics monitoring of drug response in rheumatoid arthritis in pur(epmc).pdf DeepDyve Pubget Overpricing