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10.1371/journal.pone.0200508 http://scihub22266oqcxt.onion/10.1371/journal.pone.0200508 C6047799!6047799 !30011295     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30011295 &cmd=llinks): Failed to open stream: HTTP request failed! 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Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways |pdf=|usr=}}{{30011295 }} gab.com Text Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=30011295 #FOAvip The present study was designed to investigate the pathways involved in the effect of betel nut arecoline on cell viability in 3T3-L1 preadipocytes. Arecoline, but not arecaidine or guvacine, inhibited preadipocyte viability in a concentration- and time-dependent manner. Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels. These results suggested that arecoline selectively affected a particular CDK subfamily. Arecoline inhibited AMP-activated protein kinase (AMPK) activity; conversely, the AMPK activator, AICAR, blocked the arecoline-induced inhibition of cell viability. Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins. These AMPK- and ROS-dependent effects of arecoline on preadipocyte growth may be related to the mechanism underlying the modulatory effect of arecoline on body weight. Twit Text FOAVip Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=30011295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30011295 #FOAvip English Wikipedia <ref>{{Cite pmid|30011295 }}</ref> Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways #MMPMID30011295 Tian ZH ; Weng JT ; Shih LJ ; Siao AC ; Chan TY ; Tsuei YW ; Kuo YC ; Wang TS ; Kao YH PLoS One 2018[]; 13 (7 ): e0200508 PMID30011295 show ga The present study was designed to investigate the pathways involved in the effect of betel nut arecoline on cell viability in 3T3-L1 preadipocytes. Arecoline, but not arecaidine or guvacine, inhibited preadipocyte viability in a concentration- and time-dependent manner. Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels. These results suggested that arecoline selectively affected a particular CDK subfamily. Arecoline inhibited AMP-activated protein kinase (AMPK) activity; conversely, the AMPK activator, AICAR, blocked the arecoline-induced inhibition of cell viability. Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins. These AMPK- and ROS-dependent effects of arecoline on preadipocyte growth may be related to the mechanism underlying the modulatory effect of arecoline on body weight. |3T3-L1 Cells [MESH] |AMP-Activated Protein Kinases/*metabolism [MESH] |Adipocytes/cytology/*metabolism [MESH] |Animals [MESH] |Arecoline/*pharmacology [MESH] |Cell Cycle Proteins/biosynthesis [MESH] |G2 Phase Cell Cycle Checkpoints/*drug effects [MESH] |Gene Expression Regulation/drug effects [MESH] |Mice [MESH]Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activate(epmc).pdf DeepDyve Pubget Overpricing