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2017 ; 52
(6
): 614-637
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The connections of Wnt pathway components with cell cycle and centrosome: side
effects or a hidden logic?
#MMPMID28741966
Bryja V
; ?ervenka I
; ?ajánek L
Crit Rev Biochem Mol Biol
2017[Dec]; 52
(6
): 614-637
PMID28741966
show ga
Wnt signaling cascade has developed together with multicellularity to orchestrate
the development and homeostasis of complex structures. Wnt pathway components -
such as ?-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated
proteins that emerged in evolution together with the Wnt signaling cascade and
are believed to function primarily in the Wnt cascade. It is interesting to see
that in recent literature many of these proteins are connected with cellular
functions that are more ancient and not limited to multicellular organisms - such
as cell cycle regulation, centrosome biology, or cell division. In this review,
we summarize the recent literature describing this crosstalk. Specifically, we
attempt to find the answers to the following questions: Is the response to Wnt
ligands regulated by the cell cycle? Is the centrosome and/or cilium required to
activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal
cycle and cilia formation and function? We critically review the evidence that
describes how these connections are regulated and how they help to integrate
cell-to-cell communication with the cell and the centrosomal cycle in order to
achieve a fine-tuned, physiological response.