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10.18632/oncotarget.25634 http://scihub22266oqcxt.onion/10.18632/oncotarget.25634 C6047665!6047665!30034626     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (50): 29403-13 Nephropedia Template TP {{tp|p=30034626|t=2018. Circulating tumor cells mirror bone metastatic phenotype in prostate cancer |pdf=|usr=}}{{30034626}} gab.com Text Circulating tumor cells mirror bone metastatic phenotype in prostate cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30034626 #FOAvip Circulating tumor cells (CTCs) are promising biomarkers in prostate cancer (PC) because they derive from primary tumor and metastatic tissues. In this study, we used quantitative real-time PCR (qPCR) to compare the expression profiles of 41 PC-related genes between paired CTC and spinal column metastasis samples from 22 PC patients that underwent surgery for spinal cord compression. We observed good concordance between the gene expression profiles in the CTC and metastasis samples in most of the PC patients. Expression of nine genes (AGR2, AKR1C3, AR, CDH1, FOLH1, HER2, KRT19, MDK, and SPINK1) showed a significant correlation between the CTC and metastasis samples. Hierarchical clustering analysis showed a similar grouping of PC patients based on the expression of these nine genes in both CTC and metastasis samples. Our findings demonstrate that CTCs mirror gene expression patterns in tissue metastasis samples from PC patients. Although low detection frequency of certain genes is a limitation in CTCs, our results indicate the potential for CTC phenotyping as a tool to improve individualized therapy in metastatic prostate cancer. Twit Text FOAVip Circulating tumor cells mirror bone metastatic phenotype in prostate cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30034626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30034626 #FOAvip English Wikipedia <ref>{{Cite pmid|30034626}}</ref> Circulating tumor cells mirror bone metastatic phenotype in prostate cancer #MMPMID30034626 Josefsson A; Larsson K; Månsson M; Björkman J; Rohlova E; Åhs D; Brisby H; Damber JE; Welén K Oncotarget 2018[Jun]; 9 (50): 29403-13 PMID30034626show ga Circulating tumor cells (CTCs) are promising biomarkers in prostate cancer (PC) because they derive from primary tumor and metastatic tissues. In this study, we used quantitative real-time PCR (qPCR) to compare the expression profiles of 41 PC-related genes between paired CTC and spinal column metastasis samples from 22 PC patients that underwent surgery for spinal cord compression. We observed good concordance between the gene expression profiles in the CTC and metastasis samples in most of the PC patients. Expression of nine genes (AGR2, AKR1C3, AR, CDH1, FOLH1, HER2, KRT19, MDK, and SPINK1) showed a significant correlation between the CTC and metastasis samples. Hierarchical clustering analysis showed a similar grouping of PC patients based on the expression of these nine genes in both CTC and metastasis samples. Our findings demonstrate that CTCs mirror gene expression patterns in tissue metastasis samples from PC patients. Although low detection frequency of certain genes is a limitation in CTCs, our results indicate the potential for CTC phenotyping as a tool to improve individualized therapy in metastatic prostate cancer. äCirculating tumor cells mirror bone metastatic phenotype in prostate c(epmc).pdf DeepDyve Pubget Overpricing