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10.1016/j.celrep.2018.06.003 http://scihub22266oqcxt.onion/10.1016/j.celrep.2018.06.003 C6047509!6047509!29972771     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2018 ; 24 (1): 1-10.e4 Nephropedia Template TP {{tp|p=29972771|t=2018. Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development |pdf=|usr=}}{{29972771}} gab.com Text Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29972771 #FOAvip The spatial organization of chromosomes is critical in establishing gene expression programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight into higher-order chromatin organization and dynamics. Zebrafish chromosomes segregate in active and inactive chromatin (A/B compartments), which are further organized into topologically associating domains (TADs). Zebrafish A/B compartments and TADs have genomic features similar to those of their mammalian counterparts, including evolutionary conservation and enrichment of CTCF binding sites at TAD borders. At the earliest time point, when there is no zygotic transcription, the genome is highly structured. After zygotic genome activation (ZGA), the genome loses structural features, which are re-established throughout early development. Despite the absence of structural features, we see clustering of super-enhancers in the 3D genome. Our results provide insight into vertebrate genome organization and demonstrate that the developing zebrafish embryo is a powerful model system to study the dynamics of nuclear organization. Twit Text FOAVip Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29972771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29972771 #FOAvip English Wikipedia <ref>{{Cite pmid|29972771}}</ref> Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development #MMPMID29972771 Kaaij LJ; van der Weide RH; Ketting RF; de Wit E Cell Rep 2018[Jul]; 24 (1): 1-10.e4 PMID29972771show ga The spatial organization of chromosomes is critical in establishing gene expression programs. We generated in situ Hi-C maps throughout zebrafish development to gain insight into higher-order chromatin organization and dynamics. Zebrafish chromosomes segregate in active and inactive chromatin (A/B compartments), which are further organized into topologically associating domains (TADs). Zebrafish A/B compartments and TADs have genomic features similar to those of their mammalian counterparts, including evolutionary conservation and enrichment of CTCF binding sites at TAD borders. At the earliest time point, when there is no zygotic transcription, the genome is highly structured. After zygotic genome activation (ZGA), the genome loses structural features, which are re-established throughout early development. Despite the absence of structural features, we see clustering of super-enhancers in the 3D genome. Our results provide insight into vertebrate genome organization and demonstrate that the developing zebrafish embryo is a powerful model system to study the dynamics of nuclear organization. äSystemic Loss and Gain of Chromatin Architecture throughout Zebrafish (epmc).pdf DeepDyve Pubget Overpricing