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10.1177/1849454418786159 http://scihub22266oqcxt.onion/10.1177/1849454418786159 C6047241!6047241!30023011     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Circ+Biomark 2018 ; 7 (ä): ä Nephropedia Template TP {{tp|p=30023011|t=2018. Placental protein 13: An important biological protein in preeclampsia |pdf=|usr=}}{{30023011}} gab.com Text Placental protein 13: An important biological protein in preeclampsia JO: J Circ Biomark http://www.kidney.de/pget.php?&tw=1&pmid=30023011 #FOAvip Placental protein 13 (PP13), a glycan binding protein predominantly expressed in syncytiotrophoblast, dimeric in nature, lacks N-terminal signal peptide, bypasses the endoplasmic reticulum, and secretes into maternal circulation as exosomes or microvesicles. PP13 has jelly roll fold conformation with conserved carbohydrate recognition domain which specifically binds to ?-galactosides of the glycan receptors during placentation. PP13 binds to glycosylated receptors on human erythrocytes and brings about hemagglutination by the property of lectin activity; other functions are immunoregulation and vasodilation during placentation and vascularization. The gene LGALS13 located on 19q13.2 comprising four exons expresses a 32-kDa protein with 139 amino acid residues, PP13. Impaired expression due to mutation in the gene leads to a nonfunctional truncated PP13. The low serum levels predict high risk for the onset of preeclampsia or obstetric complications. Hence, PP13 turned to be an early marker for risk assessment of preeclampsia. The recombinant PP13 and monoclonal antibodies availability help for replenishing PP13 in conditions with low serum levels and for detection and prevention of preeclampsia, respectively. Twit Text FOAVip Placental protein 13: An important biological protein in preeclampsia ????J Circ Biomark http://www.kidney.de/pget.php?&tw=1&pmid=30023011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30023011 #FOAvip English Wikipedia <ref>{{Cite pmid|30023011}}</ref> Placental protein 13: An important biological protein in preeclampsia #MMPMID30023011 Gadde R; CD D; Sheela S J Circ Biomark 2018[Jan]; 7 (ä): ä PMID30023011show ga Placental protein 13 (PP13), a glycan binding protein predominantly expressed in syncytiotrophoblast, dimeric in nature, lacks N-terminal signal peptide, bypasses the endoplasmic reticulum, and secretes into maternal circulation as exosomes or microvesicles. PP13 has jelly roll fold conformation with conserved carbohydrate recognition domain which specifically binds to ?-galactosides of the glycan receptors during placentation. PP13 binds to glycosylated receptors on human erythrocytes and brings about hemagglutination by the property of lectin activity; other functions are immunoregulation and vasodilation during placentation and vascularization. The gene LGALS13 located on 19q13.2 comprising four exons expresses a 32-kDa protein with 139 amino acid residues, PP13. Impaired expression due to mutation in the gene leads to a nonfunctional truncated PP13. The low serum levels predict high risk for the onset of preeclampsia or obstetric complications. Hence, PP13 turned to be an early marker for risk assessment of preeclampsia. The recombinant PP13 and monoclonal antibodies availability help for replenishing PP13 in conditions with low serum levels and for detection and prevention of preeclampsia, respectively. äPlacental protein 13: An important biological protein in preeclampsia (epmc).pdf DeepDyve Pubget Overpricing