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2018 ; 102
(7
): 855-862
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Global prevalence of visual impairment associated with myopic macular
degeneration and temporal trends from 2000 through 2050: systematic review,
meta-analysis and modelling
#MMPMID29699985
Fricke TR
; Jong M
; Naidoo KS
; Sankaridurg P
; Naduvilath TJ
; Ho SM
; Wong TY
; Resnikoff S
Br J Ophthalmol
2018[Jul]; 102
(7
): 855-862
PMID29699985
show ga
PURPOSE: We used systematic review and meta-analysis to identify and assimilate
evidence quantifying blindness and visual impairment (VI) associated with myopic
macular degeneration (MMD), then derived models to predict global patterns. The
models were used to estimate the global prevalence of blindness and VI associated
with MMD from 2000 to 2050. METHODS: The systematic review identified 17 papers
with prevalence data for MMD VI fitting our inclusion criteria. Data from six
papers with age-specific data were scaled to relative age-dependent risk and
meta-analysed at VI and blindness levels. We analysed variance in all MMD VI and
blindness data as a proportion of high myopia against variables from the place
and year of data collection, with a model based on health expenditure providing
the best correlation. We used this model to estimate the prevalence and number of
people with MMD VI in each country in each decade. RESULTS: We included data from
17 studies comprising 137?514 participants. We estimated 10.0?million people had
VI from MMD in 2015 (prevalence 0.13%, 95% CI 5.5 to 23.7 million,
0.07% to 0.34%), 3.3?million of whom were blind (0.04%, 1.8 to 7.8 million,
0.03% to 0.10%). We estimate that by 2050, without changing current
interventions, VI from MMD will grow to 55.7?million people (0.57%,
29.0 to 119.7?million, 0.33% to 1.11%), 18.5?million of whom will be blind
(0.19%, 9.6 to 39.7?million, 0.11% to 0.37%). CONCLUSION: The burden of MMD
blindness and VI will rise significantly without efforts to reduce the
development and progression of myopia and improve the management of MMD.