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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arch+Dis+Child+Fetal+Neonatal+Ed
2018 ; 103
(4
): F301-F306
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Neonatal brain injuries in England: population-based incidence derived from
routinely recorded clinical data held in the National Neonatal Research Database
#MMPMID29180541
Gale C
; Statnikov Y
; Jawad S
; Uthaya SN
; Modi N
Arch Dis Child Fetal Neonatal Ed
2018[Jul]; 103
(4
): F301-F306
PMID29180541
show ga
OBJECTIVE: In 2015, the Department of Health in England announced an ambition to
reduce 'brain injuries occurring during or soon after birth'. We describe the
development of a pragmatic case definition and present annual incidence rates.
DESIGN: Retrospective cohort study using data held in the National Neonatal
Research Database (NNRD) extracted from neonatal electronic patient records from
all National Health Service (NHS) neonatal units in England, Wales and Scotland.
In 2010-2011, population coverage in the NNRD was incomplete, hence rate
estimates are presented as a range; from 2012, population coverage is complete,
and rates (95% CIs) are presented. Rates are per 1000 live births. SETTING: NHS
neonatal units in England. PATIENTS: Infants admitted for neonatal care;
denominator: live births in England. MAIN OUTCOME MEASURE: 'Brain injuries
occurring at or soon after birth' defined as infants with seizures,
hypoxic-ischaemic encephalopathy, stroke, intracranial haemorrhage, central
nervous system infection and kernicterus and preterm infants with cystic
periventricular leucomalacia. RESULTS: In 2010, the lower estimate of the rate of
'Brain injuries occurring at or soon after birth' in England was 4.53 and the
upper estimate was 5.19; in 2015, the rate was 5.14 (4.97, 5.32). For preterm
infants, the population incidence in 2015 was 25.88 (24.51, 27.33) and 3.47
(3.33, 3.62) for term infants. Hypoxic-ischaemic encephalopathy was the largest
contributor to term brain injury, and intraventricular/periventricular
haemorrhage was the largest contributor to preterm brain injury. CONCLUSIONS:
Annual incidence rates for brain injuries can be estimated from data held in the
NNRD; rates for individual conditions are consistent with published rates.
Routinely recorded clinical data can be used for national surveillance, offering
efficiencies over traditional approaches.
|Brain Injuries/*epidemiology
[MESH]
|Central Nervous System Diseases/complications
[MESH]