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10.1002/rth2.12107 http://scihub22266oqcxt.onion/10.1002/rth2.12107 C6046596!6046596!30046749     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Res+Pract+Thromb+Haemost 2018 ; 2 (3): 450-60 Nephropedia Template TP {{tp|p=30046749|t=2018. Integrating platelet and coagulation activation in fibrin clot formation |pdf=|usr=}}{{30046749}} gab.com Text Integrating platelet and coagulation activation in fibrin clot formation JO: Res Pract Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=30046749 #FOAvip Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus. This review discusses current concepts of platelet control of thrombin generation, fibrin formation and structure, and anticoagulation. Indicated are how combined signalling via the platelet receptors for collagen (glycoprotein VI) and thrombin induces the secretion of (anti)coagulation factors, as well as surface exposure of phosphatidylserine, thereby catalysing thrombin generation. This procoagulant platelet response is also facilitated by the adhesive complexes glycoprotein Ib?V?IX and integrin ?IIb?3. In the buildup of a platelet?fibrin thrombus, the extrinsic, tissue factor?driven coagulation pathway is predominant in early stages, while the intrinsic, factor XII pathway seems to promote at later time points. Already early generation of thrombin enforces platelet responses and stimulates intra?thrombus heterogeneity with patches of loosely aggregated, contracted, and phosphatidylserine?exposing platelets. Fibrin actively formed on the surface of activated platelets supports thrombus growth, but also captures thrombin. The fibrin distribution in a thrombus appears to rely on the local procoagulant trigger and the blood flow rate. Clinical studies support the importance of the platelet?coagulation interplay, by showing beneficial effects of combination therapy in the secondary prevention of cardiovascular disease. Twit Text FOAVip Integrating platelet and coagulation activation in fibrin clot formation ????Res Pract Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=30046749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30046749 #FOAvip English Wikipedia <ref>{{Cite pmid|30046749}}</ref> Integrating platelet and coagulation activation in fibrin clot formation #MMPMID30046749 Swieringa F; Spronk HM; Heemskerk JW; van der Meijden PE Res Pract Thromb Haemost 2018[Jul]; 2 (3): 450-60 PMID30046749show ga Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus. This review discusses current concepts of platelet control of thrombin generation, fibrin formation and structure, and anticoagulation. Indicated are how combined signalling via the platelet receptors for collagen (glycoprotein VI) and thrombin induces the secretion of (anti)coagulation factors, as well as surface exposure of phosphatidylserine, thereby catalysing thrombin generation. This procoagulant platelet response is also facilitated by the adhesive complexes glycoprotein Ib?V?IX and integrin ?IIb?3. In the buildup of a platelet?fibrin thrombus, the extrinsic, tissue factor?driven coagulation pathway is predominant in early stages, while the intrinsic, factor XII pathway seems to promote at later time points. Already early generation of thrombin enforces platelet responses and stimulates intra?thrombus heterogeneity with patches of loosely aggregated, contracted, and phosphatidylserine?exposing platelets. Fibrin actively formed on the surface of activated platelets supports thrombus growth, but also captures thrombin. The fibrin distribution in a thrombus appears to rely on the local procoagulant trigger and the blood flow rate. Clinical studies support the importance of the platelet?coagulation interplay, by showing beneficial effects of combination therapy in the secondary prevention of cardiovascular disease. äIntegrating platelet and coagulation activation in fibrin clot formati(epmc).pdf DeepDyve Pubget Overpricing