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Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled Inflammation,
and Therapeutic Implications
#MMPMID30038616
Lin S
; Wu H
; Wang C
; Xiao Z
; Xu F
Front Immunol
2018[]; 9
(?): 1545
PMID30038616
show ga
Acute respiratory distress syndrome/acute lung injury (ALI) was described in
1967. The uncontrolled inflammation is a central issue of the syndrome. The
regulatory T cells (Tregs), formerly known as suppressor T cells, are a
subpopulation of T cells. Tregs indirectly limits immune inflammation-inflicted
tissue damage by employing multiple mechanisms and creating the appropriate
immune environment for successful tissue repair. And it plays a central role in
the resolution of ALI. Accordingly, for this review, we will focus on Treg
populations which are critical for inflammatory immunity of ALI, and the effect
of interaction between Treg subsets and cytokines on ALI. And then explore the
possibility of cytokines as beneficial factors in inflammation resolution of ALI.
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