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10.1155/2018/1419352 http://scihub22266oqcxt.onion/10.1155/2018/1419352 C6046129!6046129!30050389     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2018 ; 2018 (ä): ä Nephropedia Template TP {{tp|p=30050389|t=2018. New Insights into Behçet s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation |pdf=|usr=}}{{30050389}} gab.com Text New Insights into Behçet s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=30050389 #FOAvip To date, a major research effort on Behçet's syndrome (BS) has been concentrated on immunological aspects. Little is known about the metabolic reprogramming in BS. Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier?SLC25A1-encoded protein?it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). In induced macrophages, mitochondrial citrate is necessary for the production of inflammatory mediators. The aim of our study was to evaluate SLC25A1 and ACLY expression levels in BS patients. Following a power analysis undertaken on few random samples, the number of enrolled patients was set. Thirty-nine consecutive BS patients fulfilling ISG criteria, and 21 healthy controls suitable for age and sex were recruited. BS patients were divided into two groups according to the presence (active) or absence (inactive) of clinical manifestations. Real-time PCR experiments were performed on PBMCs to quantify SLC25A1 and ACLY mRNA levels. Data processing through the Kruskal-Wallis test and Dunn's multiple comparison test as post hoc showed higher SLC25A1 and ACLY mRNA levels in BS patients compared to those in healthy controls. Therefore, SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in BS involves the citrate pathway dysregulation. Twit Text FOAVip New Insights into Behçet s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=30050389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30050389 #FOAvip English Wikipedia <ref>{{Cite pmid|30050389}}</ref> New Insights into Behçet s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation #MMPMID30050389 Santarsiero A; Leccese P; Convertini P; Padula A; Abriola P; D'Angelo S; Bisaccia F; Infantino V Mediators Inflamm 2018[]; 2018 (ä): ä PMID30050389show ga To date, a major research effort on Behçet's syndrome (BS) has been concentrated on immunological aspects. Little is known about the metabolic reprogramming in BS. Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier?SLC25A1-encoded protein?it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). In induced macrophages, mitochondrial citrate is necessary for the production of inflammatory mediators. The aim of our study was to evaluate SLC25A1 and ACLY expression levels in BS patients. Following a power analysis undertaken on few random samples, the number of enrolled patients was set. Thirty-nine consecutive BS patients fulfilling ISG criteria, and 21 healthy controls suitable for age and sex were recruited. BS patients were divided into two groups according to the presence (active) or absence (inactive) of clinical manifestations. Real-time PCR experiments were performed on PBMCs to quantify SLC25A1 and ACLY mRNA levels. Data processing through the Kruskal-Wallis test and Dunn's multiple comparison test as post hoc showed higher SLC25A1 and ACLY mRNA levels in BS patients compared to those in healthy controls. Therefore, SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in BS involves the citrate pathway dysregulation. äNew Insights into Behçet s Syndrome Metabolic Reprogramming: Citrate P(epmc).pdf DeepDyve Pubget Overpricing