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10.1186/s12882-018-0963-9 http://scihub22266oqcxt.onion/10.1186/s12882-018-0963-9 C6045876!6045876!30005632     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Nephrol 2018 ; 19 (ä): ä Nephropedia Template TP {{tp|p=30005632|t=2018. Rehydration with fructose worsens dehydration-induced renal damage |pdf=|usr=}}{{30005632}} gab.com Text Rehydration with fructose worsens dehydration-induced renal damage JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=30005632 #FOAvip Background: Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have recently reported a model of CKD induced by heat stress. Here we test the hypothesis that rehydration with fructose may induce worse kidney injury than rehydration with equal amounts of water, and we also test if this fructose-induced injury is associated with activation of inflammasomes in the kidney. Methods: Mice were recurrently exposed to heat (39.5 C0 for 30 min/h, 5 times daily for 5 wks) with rehydration consisting of 6 ml each night of water (Heat, n?=?7) or fructose (Heat+F, 10%, n?=?7), and were compared to control mice on water (Control, n?=?7) or fructose (Fructose, n?=?7). Various markers of renal injury were assessed. Results: Compared to control animals, there was a progressive worsening of renal injury (inflammation and fibrosis) with fructose alone, heat stress alone, and heat stress with fructose rehydration (P?<?0.01 by ANOVA). The combination of heat stress with rehydration with fructose was associated with increased intrarenal expression of the inflammasome markers, NLRP3 and IL-18, compared to heat stress alone. In addition, heat stress with or without fructose was associated with increased expression of caspase ??3 and monocyte chemoattractant protein-1 levels. Fructose administration was also associated with an increase in serum copeptin levels (a biomarker of vasopressin) and elevated copeptin was also observed in mice undergoing heat stress alone. Conclusions: These studies suggest that heat stress may activate intrarenal inflammasomes leading to inflammation and renal injury, and provide evidence that rehydration with fructose may accelerate the renal injury and inflammatory response. Twit Text FOAVip Rehydration with fructose worsens dehydration-induced renal damage ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=30005632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30005632 #FOAvip English Wikipedia <ref>{{Cite pmid|30005632}}</ref> Rehydration with fructose worsens dehydration-induced renal damage #MMPMID30005632 Milagres T; García-Arroyo FE; Lanaspa MA; Garcia G; Ishimoto T; Andres-Hernando A; Kuwabara M; Jensen T; Sato Y; Glaser J; Sánchez-Lozada LG; Johnson RJ; Roncal-Jimenez C BMC Nephrol 2018[]; 19 (ä): ä PMID30005632show ga Background: Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have recently reported a model of CKD induced by heat stress. Here we test the hypothesis that rehydration with fructose may induce worse kidney injury than rehydration with equal amounts of water, and we also test if this fructose-induced injury is associated with activation of inflammasomes in the kidney. Methods: Mice were recurrently exposed to heat (39.5 C0 for 30 min/h, 5 times daily for 5 wks) with rehydration consisting of 6 ml each night of water (Heat, n?=?7) or fructose (Heat+F, 10%, n?=?7), and were compared to control mice on water (Control, n?=?7) or fructose (Fructose, n?=?7). Various markers of renal injury were assessed. Results: Compared to control animals, there was a progressive worsening of renal injury (inflammation and fibrosis) with fructose alone, heat stress alone, and heat stress with fructose rehydration (P? äRehydration with fructose worsens dehydration-induced renal damage (epmc).pdf DeepDyve Pubget Overpricing