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10.1186/s12885-018-4594-0 http://scihub22266oqcxt.onion/10.1186/s12885-018-4594-0 C6045826!6045826 !30005627     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30005627 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2(+) breast cancer samples |pdf=|usr=}}{{30005627 }} gab.com Text Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2(+) breast cancer samples JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=30005627 #FOAvip BACKGROUND: HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events. METHODS: We interrogated the genomic structure of 18 clinically-defined HER2+ breast tumors through integrated analysis of whole genome and transcriptome sequencing, coupled with clinical information. RESULTS: ERBB2 overexpression in 15 of these tumors was associated with ERBB2 amplification due to chromoanasynthesis with six of them containing single events and the other nine exhibiting multiple events. Two of the more complex cases had adverse clinical outcomes. Chromosomes 8 was commonly involved in the same chromoanasynthesis with 17. In ten cases where chromosome 8 was involved we observed NRG1 fusions (two cases), NRG1 amplification (one case), FGFR1 amplification and ADAM32 or ADAM5 fusions. ERBB3 over-expression was associated with NRG1 fusions and EGFR and ERBB3 expressions were anti-correlated. Of the remaining three cases, one had a small duplication fully encompassing ERBB2 and was accompanied with a pathogenic mutation. CONCLUSION: Chromoanasynthesis involving chromosome 17 can lead to ERBB2 amplifications in HER2+ breast cancer. However, additional large genomic alterations contribute to a high level of genomic complexity, generating the hypothesis that worse outcome could be associated with multiple chromoanasynthetic events. Twit Text FOAVip Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2(+) breast cancer samples ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=30005627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30005627 #FOAvip English Wikipedia <ref>{{Cite pmid|30005627 }}</ref> Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2(+) breast cancer samples #MMPMID30005627 Vasmatzis G ; Wang X ; Smadbeck JB ; Murphy SJ ; Geiersbach KB ; Johnson SH ; Gaitatzes AG ; Asmann YW ; Kosari F ; Borad MJ ; Serie DJ ; McLaughlin SA ; Kachergus JM ; Necela BM ; Thompson EA BMC Cancer 2018[Jul]; 18 (1 ): 738 PMID30005627 show ga BACKGROUND: HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events. METHODS: We interrogated the genomic structure of 18 clinically-defined HER2+ breast tumors through integrated analysis of whole genome and transcriptome sequencing, coupled with clinical information. RESULTS: ERBB2 overexpression in 15 of these tumors was associated with ERBB2 amplification due to chromoanasynthesis with six of them containing single events and the other nine exhibiting multiple events. Two of the more complex cases had adverse clinical outcomes. Chromosomes 8 was commonly involved in the same chromoanasynthesis with 17. In ten cases where chromosome 8 was involved we observed NRG1 fusions (two cases), NRG1 amplification (one case), FGFR1 amplification and ADAM32 or ADAM5 fusions. ERBB3 over-expression was associated with NRG1 fusions and EGFR and ERBB3 expressions were anti-correlated. Of the remaining three cases, one had a small duplication fully encompassing ERBB2 and was accompanied with a pathogenic mutation. CONCLUSION: Chromoanasynthesis involving chromosome 17 can lead to ERBB2 amplifications in HER2+ breast cancer. However, additional large genomic alterations contribute to a high level of genomic complexity, generating the hypothesis that worse outcome could be associated with multiple chromoanasynthetic events. |*Chromothripsis [MESH] |*Gene Amplification [MESH] |Breast Neoplasms/chemistry/*genetics/pathology [MESH] |Chromosomes, Human, Pair 17 [MESH] |Cohort Studies [MESH] |Female [MESH] |Humans [MESH] |Neoplasm Staging [MESH]Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifica(epmc).pdf DeepDyve Pubget Overpricing