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10.1038/s41467-018-05039-1 http://scihub22266oqcxt.onion/10.1038/s41467-018-05039-1 C6045644!6045644!30006544     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30006544|t=2018. HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development |pdf=|usr=}}{{30006544}} gab.com Text HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30006544 #FOAvip Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates. By analyzing zebrafish mutants, we found that hhex is necessary for sprouting angiogenesis from the posterior cardinal vein, a process required for lymphangiogenesis. Furthermore, studies of mammalian HHEX using tissue-specific genetic deletions in mouse and knockdowns in cultured human endothelial cells reveal its highly conserved function during vascular and lymphatic development. Our findings that HHEX is essential for the regulation of the VEGFC/FLT4/PROX1 axis provide insights into the molecular regulation of lymphangiogenesis. Twit Text FOAVip HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30006544 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30006544 #FOAvip English Wikipedia <ref>{{Cite pmid|30006544}}</ref> HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development #MMPMID30006544 Gauvrit S; Villasenor A; Strilic B; Kitchen P; Collins MM; Marín-Juez R; Guenther S; Maischein HM; Fukuda N; Canham MA; Brickman JM; Bogue CW; Jayaraman PS; Stainier DYR Nat Commun 2018[]; 9 (ä): ä PMID30006544show ga Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically expressed homeobox (HHEX) as an upstream regulator of VEGFC, FLT4, and PROX1 during angiogenic sprouting and lymphatic formation in vertebrates. By analyzing zebrafish mutants, we found that hhex is necessary for sprouting angiogenesis from the posterior cardinal vein, a process required for lymphangiogenesis. Furthermore, studies of mammalian HHEX using tissue-specific genetic deletions in mouse and knockdowns in cultured human endothelial cells reveal its highly conserved function during vascular and lymphatic development. Our findings that HHEX is essential for the regulation of the VEGFC/FLT4/PROX1 axis provide insights into the molecular regulation of lymphangiogenesis. äHHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling (epmc).pdf DeepDyve Pubget Overpricing