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10.1038/s41467-018-05288-0 http://scihub22266oqcxt.onion/10.1038/s41467-018-05288-0 C6045629!6045629 !30006605     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30006605 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling |pdf=|usr=}}{{30006605 }} gab.com Text Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30006605 #FOAvip Foreign antigens are presented by antigen-presenting cells in the presence of abundant endogenous peptides that are nonstimulatory to the T cell. In mouse T cells, endogenous, nonstimulatory peptides have been shown to enhance responses to specific peptide antigens, a phenomenon termed coagonism. However, whether coagonism also occurs in human T cells is unclear, and the molecular mechanism of coagonism is still under debate since CD4 and CD8 coagonism requires different interactions. Here we show that the nonstimulatory, HIV-derived peptide GAG enhances a specific human cytotoxic T lymphocyte response to HBV-derived epitopes presented by HLA-A*02:01. Coagonism in human T cells requires the CD8 coreceptor, but not T-cell receptor (TCR) binding to the nonstimulatory peptide-MHC. Coagonists enhance the phosphorylation and recruitment of several molecules involved in the TCR-proximal signaling pathway, suggesting that coagonists promote T-cell responses to antigenic pMHC by amplifying TCR-proximal signaling. Twit Text FOAVip Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30006605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30006605 #FOAvip English Wikipedia <ref>{{Cite pmid|30006605 }}</ref> Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling #MMPMID30006605 Zhao X ; Sankaran S ; Yap J ; Too CT ; Ho ZZ ; Dolton G ; Legut M ; Ren EC ; Sewell AK ; Bertoletti A ; MacAry PA ; Brzostek J ; Gascoigne NRJ Nat Commun 2018[Jul]; 9 (1 ): 2716 PMID30006605 show ga Foreign antigens are presented by antigen-presenting cells in the presence of abundant endogenous peptides that are nonstimulatory to the T cell. In mouse T cells, endogenous, nonstimulatory peptides have been shown to enhance responses to specific peptide antigens, a phenomenon termed coagonism. However, whether coagonism also occurs in human T cells is unclear, and the molecular mechanism of coagonism is still under debate since CD4 and CD8 coagonism requires different interactions. Here we show that the nonstimulatory, HIV-derived peptide GAG enhances a specific human cytotoxic T lymphocyte response to HBV-derived epitopes presented by HLA-A*02:01. Coagonism in human T cells requires the CD8 coreceptor, but not T-cell receptor (TCR) binding to the nonstimulatory peptide-MHC. Coagonists enhance the phosphorylation and recruitment of several molecules involved in the TCR-proximal signaling pathway, suggesting that coagonists promote T-cell responses to antigenic pMHC by amplifying TCR-proximal signaling. |Amino Acid Sequence [MESH] |Animals [MESH] |Antigen Presentation [MESH] |Antigen-Presenting Cells/cytology/immunology [MESH] |Antigens/chemistry/genetics/*immunology [MESH] |CHO Cells [MESH] |Cricetulus [MESH] |Epitopes/chemistry/genetics/*immunology [MESH] |Gene Expression [MESH] |HLA-A2 Antigen/genetics/*immunology [MESH] |Humans [MESH] |Immunological Synapses/immunology/ultrastructure [MESH] |Lymphocyte Activation [MESH] |Peptides/chemistry/genetics/*immunology [MESH] |Plasmids/chemistry/immunology [MESH] |Receptors, Antigen, T-Cell/chemistry/genetics/*immunology [MESH] |Recombinant Fusion Proteins/genetics/immunology [MESH] |Signal Transduction/*immunology [MESH] |T-Lymphocytes, Cytotoxic/cytology/*immunology [MESH] |Transfection [MESH]Nonstimulatory peptide-MHC enhances human T-cell antigen-specific resp(epmc).pdf DeepDyve Pubget Overpricing