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10.1021/acsomega.7b01890 http://scihub22266oqcxt.onion/10.1021/acsomega.7b01890 C6045326!6045326!30023844     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Omega 2018 ; 3 (3): 2652-60 Nephropedia Template TP {{tp|p=30023844|t=2018. Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury |pdf=|usr=}}{{30023844}} gab.com Text Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023844 #FOAvip This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol?glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by 1H NMR, 13C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on renal ischemia?reperfusion injury animal models. The results demonstrated that the decorated compound CLG could completely reverse the disease progression as same as CLT. Furthermore, the toxicity of CLG was also fully evaluated in rat blood, liver, kidney, heart, spleen, lung, and reproductive system. Compared to the performance of CLT on normal organs, CLG could remarkably maintain high safety and significantly reduce the side effects. Taken together, the CLG could keep the same efficacy as CLT while processing lower toxicity in vivo. Twit Text FOAVip Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30023844 #FOAvip English Wikipedia <ref>{{Cite pmid|30023844}}</ref> Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury #MMPMID30023844 Hu X; Jia M; Fu Y; Zhang P; Zhang Z; Lin Q ACS Omega 2018[Mar]; 3 (3): 2652-60 PMID30023844show ga This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol?glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by 1H NMR, 13C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on renal ischemia?reperfusion injury animal models. The results demonstrated that the decorated compound CLG could completely reverse the disease progression as same as CLT. Furthermore, the toxicity of CLG was also fully evaluated in rat blood, liver, kidney, heart, spleen, lung, and reproductive system. Compared to the performance of CLT on normal organs, CLG could remarkably maintain high safety and significantly reduce the side effects. Taken together, the CLG could keep the same efficacy as CLT while processing lower toxicity in vivo. äNovel Low-Toxic Derivative of Celastrol Maintains Protective Effect ag(epmc).pdf DeepDyve Pubget Overpricing