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10.1021/acsomega.8b00475 http://scihub22266oqcxt.onion/10.1021/acsomega.8b00475 C6044748!6044748 !30023962     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30023962 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Omega 2018 ; 3 (6 ): 6812-6819 Nephropedia Template TP {{tp|p=30023962 |t=2018. Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model |pdf=|usr=}}{{30023962 }} gab.com Text Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023962 #FOAvip We report herein an investigation of carbazole-based cyanine, (E)-4-(2-(9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide (SLM), as an effective theranostic agent for Alzheimer's disease (AD). This cyanine exhibited desirable multifunctional and biological properties, including amyloid-? (A?)-oligomerization inhibition, blood-brain barrier permeability, low neurotoxicity, neuroprotective effect against A?-induced toxicities, high selectivity and strong binding interactions with A? peptide/species, good biostability, as well as strong fluorescence enhancement upon binding to A? species for diagnosis and therapy of AD. This cyanine has been successfully applied to perform near-infrared in vivo imaging of A? species in transgenic AD mouse model. The triple transgenic AD mice intraperitoneally treated with SLM showed significant recovery of cognitive deficits. Furthermore, those SLM-treated mice exhibited a substantial decrease in both of oligomeric A? contents and tau proteins in their brain, which was attributed to the induction of autophagic flux. These findings demonstrated for the first time that SLM is an effective theranostic agent with in vivo efficacy for diagnosis and treatment of AD in mouse models. Twit Text FOAVip Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30023962 #FOAvip English Wikipedia <ref>{{Cite pmid|30023962 }}</ref> Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model #MMPMID30023962 Li Y ; Chen C ; Xu D ; Poon CY ; Ho SL ; Zheng R ; Liu Q ; Song G ; Li HW ; Wong MS ACS Omega 2018[Jun]; 3 (6 ): 6812-6819 PMID30023962 show ga We report herein an investigation of carbazole-based cyanine, (E)-4-(2-(9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide (SLM), as an effective theranostic agent for Alzheimer's disease (AD). This cyanine exhibited desirable multifunctional and biological properties, including amyloid-? (A?)-oligomerization inhibition, blood-brain barrier permeability, low neurotoxicity, neuroprotective effect against A?-induced toxicities, high selectivity and strong binding interactions with A? peptide/species, good biostability, as well as strong fluorescence enhancement upon binding to A? species for diagnosis and therapy of AD. This cyanine has been successfully applied to perform near-infrared in vivo imaging of A? species in transgenic AD mouse model. The triple transgenic AD mice intraperitoneally treated with SLM showed significant recovery of cognitive deficits. Furthermore, those SLM-treated mice exhibited a substantial decrease in both of oligomeric A? contents and tau proteins in their brain, which was attributed to the induction of autophagic flux. These findings demonstrated for the first time that SLM is an effective theranostic agent with in vivo efficacy for diagnosis and treatment of AD in mouse models. äEffective Theranostic Cyanine for Imaging of Amyloid Species in Vivo a(epmc).pdf DeepDyve Pubget Overpricing