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10.1021/acsomega.8b00521 http://scihub22266oqcxt.onion/10.1021/acsomega.8b00521 C6044561!6044561!30023914     free     free     free       ACS+Omega 2018 ; 3 (5): 5273-80 Nephropedia Template TP {{tp|p=30023914|t=2018. Artificial 3D Culture Systems for T Cell Expansion |pdf=|usr=}}{{30023914}} gab.com Text Artificial 3D Culture Systems for T Cell Expansion JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023914 #FOAvip Adoptive cell therapy, i.e., the extraction, manipulation, and administration of ex vivo generated autologous T cells to patients, is an emerging alternative to regular procedures in cancer treatment. Nevertheless, these personalized treatments require laborious and expensive laboratory procedures that should be alleviated to enable their incorporation into the clinics. With the objective to improve the ex vivo expansion of large amount of specific T cells, we propose the use of three-dimensional (3D) structures during their activation with artificial antigen-presenting cells, thus resembling the natural environment of the secondary lymphoid organs. Thus, the activation, proliferation, and differentiation of T cells have been analyzed when cultured in the presence of two 3D systems, Matrigel and a 3D polystyrene scaffold, showing an increase in cell proliferation compared to standard suspension systems. Twit Text FOAVip Artificial 3D Culture Systems for T Cell Expansion ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=30023914 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30023914 #FOAvip English Wikipedia <ref>{{Cite pmid|30023914}}</ref> Artificial 3D Culture Systems for T Cell Expansion #MMPMID30023914 Pérez del Río E; Martinez Miguel M; Veciana J; Ratera I; Guasch J ACS Omega 2018[May]; 3 (5): 5273-80 PMID30023914show ga Adoptive cell therapy, i.e., the extraction, manipulation, and administration of ex vivo generated autologous T cells to patients, is an emerging alternative to regular procedures in cancer treatment. Nevertheless, these personalized treatments require laborious and expensive laboratory procedures that should be alleviated to enable their incorporation into the clinics. With the objective to improve the ex vivo expansion of large amount of specific T cells, we propose the use of three-dimensional (3D) structures during their activation with artificial antigen-presenting cells, thus resembling the natural environment of the secondary lymphoid organs. Thus, the activation, proliferation, and differentiation of T cells have been analyzed when cultured in the presence of two 3D systems, Matrigel and a 3D polystyrene scaffold, showing an increase in cell proliferation compared to standard suspension systems. äArtificial 3D Culture Systems for T Cell Expansion (epmc).pdf DeepDyve Pubget Overpricing