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10.1016/j.immuni.2015.09.003 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.09.003 C6044435!6044435!26431948     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2015 ; 43 (4): 727-38 Nephropedia Template TP {{tp|p=26431948|t=2015. IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability |pdf=|usr=}}{{26431948}} gab.com Text IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26431948 #FOAvip Whether IL-17A has pathogenic and/or protective roles in the gut mucosa is controversial and few studies have analyzed specific cell populations for protective functions within the inflamed colonic tissue. Here we provide evidence for IL-17A dependent regulation of the tight junction protein occludin during epithelial injury that limits excessive permeability and maintains barrier integrity. Analysis of epithelial cells showed that in the absence of Act-1 signaling, the protective effect of IL-17A was abrogated and inflammation was enhanced. We demonstrate that following acute intestinal injury, IL-23R+ ROR?t+ ?? T cells in the colonic lamina propria are the primary producers of early, gut-protective IL-17A, over other cell populations such as memory Th17 cells and ILC3. This production of IL-17A was IL-23 independent, leaving protective IL-17 intact in the absence of IL-23. These results suggest that IL-17 producing resident ?? T cells are important for the maintenance, and protectionof epithelial barriers in the intestinal mucosa. Twit Text FOAVip IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=26431948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26431948 #FOAvip English Wikipedia <ref>{{Cite pmid|26431948}}</ref> IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability #MMPMID26431948 Lee JS; Tato CM; Joyce-Shaikh B; Gulan F; Cayatte C; Chen Y; Blumenschein WM; Judo M; Chen K; Ayanoglu G; McClanahan TK; Li X; Cua DJ Immunity 2015[Oct]; 43 (4): 727-38 PMID26431948show ga Whether IL-17A has pathogenic and/or protective roles in the gut mucosa is controversial and few studies have analyzed specific cell populations for protective functions within the inflamed colonic tissue. Here we provide evidence for IL-17A dependent regulation of the tight junction protein occludin during epithelial injury that limits excessive permeability and maintains barrier integrity. Analysis of epithelial cells showed that in the absence of Act-1 signaling, the protective effect of IL-17A was abrogated and inflammation was enhanced. We demonstrate that following acute intestinal injury, IL-23R+ ROR?t+ ?? T cells in the colonic lamina propria are the primary producers of early, gut-protective IL-17A, over other cell populations such as memory Th17 cells and ILC3. This production of IL-17A was IL-23 independent, leaving protective IL-17 intact in the absence of IL-23. These results suggest that IL-17 producing resident ?? T cells are important for the maintenance, and protectionof epithelial barriers in the intestinal mucosa. äIL-23-Independent IL-17 Production Regulates Intestinal Epithelial Per(epmc).pdf DeepDyve Pubget Overpricing